...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Comparative study of seeding methods for three-dimensional polymeric scaffolds
【24h】

Comparative study of seeding methods for three-dimensional polymeric scaffolds

机译：三维聚合物支架播种方法的比较研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Development of tissue-engineered devices may be enhanced by combining cells with porous absorbable polymeric scaffolds before implantation. The cells are seeded throughout the scaffolds and allowed to proliferate in vitro for a predetermined amount of time. The distribution of cells throughout the porous material is one critical component determining success or failure of the tissue-engineered device. This can influence both the successful integration of the device with the host tissue as well as the development of a vascularized network throughout the entire scaffold volume. This research sought to compare different seeding and proliferation methods to select an ideal method for a polyglycolide/aortic endothelial cell system. Two seeding environments, static and dynamic, and three proliferation environments, static, dynamic, and bioreactor, were analyzed, for a total of six possible methods. The six seeding and proliferation combinations were analyzed following a 1-week total culture time. It was determined that for this specific system, dynamic seeding followed by a dynamic proliferation phase is the least promising method and dynamic seeding followed by a bioreactor proliferation phase is the most promising.
机译：通过在植入前将细胞与可吸收的多孔聚合物支架相结合，可以增强组织工程设备的开发。将细胞接种在整个支架中，并使其在体外增殖预定时间。细胞在整个多孔材料中的分布是决定组织工程设备成功与否的一个关键因素。这可以影响装置与宿主组织的成功整合以及在整个支架体积中血管化网络的发展。这项研究试图比较不同的播种和增殖方法，以便为聚乙交酯/主动脉内皮细胞系统选择理想的方法。分析了两种播种环境（静态和动态）以及三种增殖环境（静态，动态和生物反应器），共计六种可能的方法。经过1周的总培养时间后，分析了6种接种和增殖组合。已确定，对于该特定系统，动态播种然后动态增殖阶段是最有前途的方法，动态播种然后是生物反应器增殖阶段是最有前途的方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号