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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Two different types of nonthrombogenic surfaces: PEG suppresses platelet adhesion ATP-independently but HEMA-St block copolymer requires ATP consumption of platelets to prevent adhesion.
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Two different types of nonthrombogenic surfaces: PEG suppresses platelet adhesion ATP-independently but HEMA-St block copolymer requires ATP consumption of platelets to prevent adhesion.

机译：两种不同类型的非血栓形成表面：PEG单独抑制ATP的血小板粘附，但是HEMA-St嵌段共聚物需要消耗ATP的血小板以防止粘附。

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摘要

Poly(ethylene glycol) (PEG) and a hydrophobic-hydrophilic microdomain structured block copolymer comprising poly(2-hydroxyethyl methacrylate) and polystyrene (HEMA-St) have been reported to show good blood compatibility owing to inhibition of platelet activation. By using a computer-assisted novel technique to analyze platelet behavior on the surfaces, we found two different mechanisms to prevent platelet adhesion. Platelets were prevented from adhesion and spreading on the microdomain surface and retained cell movement for a long time. The platelet movement velocity was not significantly different between PEG-grafted surfaces and HEMA-St block copolymer-cast surfaces. However, platelet motion was qualitatively different. Platelets on HEMA-St block copolymer-cast surfaces moved with rolling, spinning, and vibrating, whereas platelet movement was limited to oscillatory vibration on PEG-grafted surfaces. When platelets were treated with NaN(3), an adenosine triphosphate (ATP) synthesis inhibitor, before contacting the surfaces, platelets movement velocity was decreased only on HEMA-St block copolymer-cast surfaces. Such an inhibitory effect was hardly observed with platelets on PEG-grafted surfaces. We propose two different mechanisms to prevent platelet adhesion onto surfaces. One is ATP-independent as observed with PEG, and the other is ATP-dependent for HEMA-St block copolymer, where platelets consume ATP to prevent adhesion. Copyright 2000 John Wiley & Sons, Inc.
机译：据报道，由于抑制血小板活化，聚（乙二醇）（PEG）和包含聚（甲基丙烯酸2-羟乙酯）和聚苯乙烯（HEMA-St）的疏水性亲水微区结构嵌段共聚物显示出良好的血液相容性。通过使用计算机辅助的新技术来分析表面上的血小板行为，我们发现了两种防止血小板粘附的机制。防止血小板粘附和散布在微区表面上并长时间保留细胞运动。 PEG接枝表面和HEMA-St嵌段共聚物浇铸表面之间的血小板运动速度没有显着差异。但是，血小板运动在质量上是不同的。 HEMA-St嵌段共聚物浇铸表面上的血小板随着滚动，旋转和振动而移动，而血小板的移动仅限于PEG接枝表面的振荡振动。当用NaN（3），一种三磷酸腺苷（ATP）合成抑制剂处理血小板时，接触表面之前，血小板运动速度仅在HEMA-St嵌段共聚物浇铸表面上降低。用血小板在PEG接枝的表面上几乎观察不到这种抑制作用。我们提出了两种不同的机制来防止血小板粘附到表面上。一个是如PEG所观察到的，与ATP无关，另一个与HEMA-St嵌段共聚物的ATP无关，其中血小板消耗ATP来防止粘附。版权所有2000 John Wiley＆Sons，Inc.

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