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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Improvement of swelling properties of poly(2-hydroxyethyl methacrylate) hydrogel by means of biomimetic method
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Improvement of swelling properties of poly(2-hydroxyethyl methacrylate) hydrogel by means of biomimetic method

机译:仿生法改善聚甲基丙烯酸2-羟乙酯水凝胶的溶胀性能

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摘要

Poly(2-hydroxyethyl methacrylates) (PHEMAs) structurally modified by means of polymer blends and random copolymers are intensively studied in order to improve mechanical properties. It was recently shown that a hydroxyapatite coating, which should improve the bonding of this biomaterial to the bone, can be obtained by means of the biomimetic method. When PHEMA is submitted to the biomimetic method, its swelling ratio is improved. This can be ascribed to the deposition of a silicatic layer, which improves the hydrophilicity, on the surface of the internal pores during the first stage of the method. This appears to be a valuable result for producing modified PHEMAs with improved mechanical properties and good swelling. The experimental results indicate the following: stronger interactions with the water molecules are set up, an induction period is observed that is linked to the rate of the reactions occurring at the surface of the glass and the establishment of a convenient concentration of the silicate ions at the external surface of the polymer, and the diffusion of simulated body fluid into the pores is the limiting stage of the process.
机译:为了改善机械性能,深入研究了通过聚合物共混物和无规共聚物进行结构改性的聚(甲基丙烯酸2-羟乙酯)(PHEMA)。最近显示,可以通过仿生方法获得应改善该生物材料与骨骼的结合的羟基磷灰石涂层。当PHEMA应用于仿生方法时,其溶胀率得到改善。这可以归因于在方法的第一阶段在内部孔的表面上沉积了二氧化硅层,其改善了亲水性。这似乎是生产具有改进的机械性能和良好溶胀性的改性PHEMA的有价值的结果。实验结果表明:与水分子建立了更强的相互作用,观察到一个诱导期,该诱导期与玻璃表面发生的反应速率有关,并且在硅酸盐中建立了方便的硅酸盐离子浓度。聚合物的外表面以及模拟体液向孔中的扩散是该过程的限制阶段。

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