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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Does surface chemistry affect thrombogenicity of surface modified polymers?
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Does surface chemistry affect thrombogenicity of surface modified polymers?

机译：表面化学会影响表面改性聚合物的血栓形成性吗？

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With some exceptions, surface chemistry had little effect on platelet and leukocyte activation, and cell deposition, by scanning electron microscopy after blood exposure and clotting times among a group of 12 unmodified and plasma modified tubings. All materials activated platelets and leukocytes to detectable levels, although some materials increased the value of one activation parameter but not another. Unmodified materials (polyethylene (PE), Pellethane~? (PEU), latex, nylon, and Silastic~?) and modified materials (H_2O plasma treated PE and PEU, CF_4 plasma treated PE, fluorinated PEU, NH_4 plasma treated PEU, polyethylene imine treated PEU, and heparin treated PEU) were characterised by XPS and contact angle. The objective of this project was to define a series of assays for the evaluation of hemocompatibility of cardiovascular devices with a view to clarify the specific requirements of ISO-10993-4, and to define an appropriate screening program for new blood contacting biomaterials. PE, PE-CF_4, PE-H_2O, PEU-F, latex, and PEU-heparin were the exceptions to the general observations, although each behaved differently. PE proved to be least reactive, whereas PE-CF_4 was most reactive by several assays. Platelet microparticle formation (determined by flow cytometry), PTT, postblood exposure SEM, total SC5b-9, C3a, and platelet and leukocyte loss (cell counts) were able to distinguish differences among these materials, and often, but not always, showed expected correlations.
机译：除某些例外，在12个未修饰和血浆修饰的导管中，通过血液暴露和凝结时间后的扫描电子显微镜，表面化学对血小板和白细胞的活化以及细胞沉积的影响很小。所有材料都将血小板和白细胞激活到可检测的水平，尽管某些材料增加了一个激活参数的值，但没有另一个。未改性的材料（聚乙烯（PE），Pellethane〜？（PEU），乳胶，尼龙和Silastic〜？）和改性的材料（H_2O等离子体处理的PE和PEU，CF_4等离子体处理的PE，氟化PEU，NH_4等离子体处理的PEU，聚乙烯亚胺用XPS和接触角来表征经处理的PEU和经肝素处理的PEU。该项目的目的是定义一系列用于评估心血管设备血液相容性的分析方法，以阐明ISO-10993-4的具体要求，并为新的接触血液的生物材料定义适当的筛查程序。 PE，PE-CF_4，PE-H_2O，PEU-F，乳胶和PEU-肝素是一般观察的例外，尽管它们的表现各不相同。经多次试验证明，PE的反应性最低，而PE-CF_4的反应性最高。血小板微粒形成（通过流式细胞术确定），PTT，血后暴露SEM，总SC5b-9，C3a以及血小板和白细胞损失（细胞计数）能够区分这些物质之间的差异，而且通常但并非总是如此相关性。

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