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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Encapsulation of isotope on novel #beta#-emitting poly (ethylene terephthalate) surfaces
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Encapsulation of isotope on novel #beta#-emitting poly (ethylene terephthalate) surfaces

机译：新型＃beta＃发射聚对苯二甲酸乙二醇酯表面上的同位素包封

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Recent data indicate that intravascular #beta#a-irradiation from centrally located sources at the time of balloon angioplasty or stenting reduces proliferation of smooth muscle cells, neointima formation, and restenosis. In an effort to simplify radiation delivery, a novel #mu#-radiation source was developed based on the adso rption of ~(32)P (phosphoric acid) by pH-sensitive chitosan hydrogel on a poly (ethylene terephthalate) balloon surface. To prevent the ~(32)P-isotope desorption in the patient's blood, the adsorbed phosphoric acid wad precipitated as CaHPO_4 on the surface by a saturated Ca(OH)_2/5percent CaCl_2 solution. Various polyurethanes were applied to seal the radioactive surface by the dip-coating method. The isotope off-rate results were determined. Optimal results were obtained by serially coating with two polyurethane solutions. This approach holds promise for simplifying and improving the safety, and minimizing the cost of intravascular brachytherapy.
机译：最新数据表明，在球囊血管成形术或支架置入术中，从位于中心位置的源进行血管内＃beta＃a辐射可减少平滑肌细胞的增殖，新内膜形成和再狭窄。为了简化辐射的传输，基于pH敏感的壳聚糖水凝胶在聚对苯二甲酸乙二酯球囊表面吸附〜（32）P（磷酸），开发了一种新型的＃mu＃辐射源。为了防止〜（32）P同位素在患者血液中解吸，被吸附的磷酸通过饱和Ca（OH）_2 / 5％CaCl_2溶液以CaHPO_4的形式沉淀在表面。通过浸涂法施加各种聚氨酯以密封放射性表面。确定了同位素失速结果。通过连续涂布两种聚氨酯溶液可获得最佳结果。这种方法有望简化和提高安全性，并使血管内近距离放射治疗的成本降至最低。

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