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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >An Investigation of the Cytotoxicity and Histocompatibility of In Situ Forming Lactic Acid Based Orthopedic Biomaterials
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An Investigation of the Cytotoxicity and Histocompatibility of In Situ Forming Lactic Acid Based Orthopedic Biomaterials

机译：原位形成乳酸基骨科生物材料的细胞毒性和组织相容性研究

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摘要

The cytotoxicity and biocompatibility of polymer networks prefabricated from multifunctional lactic acid based oligomers that are being developed for orthopedic applications were assessed through in vitro cytotoxicity analysis and subcutaneous implantation. After 7 and 14 days, no significant difference was observed in the relative viability or alkaline phosphatase activity of primary rat calvarial osteoblasts cultured in the presence or absence of degrading polymer networks, indicating that the degradation products had no detrimental effect on the function or activity of the cultured cells. The tissue response to preformed lactic acid networks implanted in rats consisted of a mild inflammatory response with an increase in fibrous capsule thickness and inflammation correlating with faster degrading polymer compositions. This relatively neutral response is indicative of a biocompatible, degradable polymer that has potential medical applications. Finally, porous scaffolds were implanted subcutaneously in rats, and vascularized fibrous tissue infiltration was highly dependent on the scaffold porosity and architecture. This finding indicates that an in situ forming porous scaffold of this composition may support the infiltration of surrounding vascularized tissue, and thus be applicable to orthopedic treatments of large bone defects.
机译：通过体外细胞毒性分析和皮下植入，评估了由多功能乳酸基寡聚物预制而成的聚合物网络的细胞毒性和生物相容性，这些低聚物正为骨科应用而开发。 7天和14天后，在存在或不存在降解聚合物网络的情况下培养的原代大鼠颅骨成骨细胞的相对生存力或碱性磷酸酶活性均未观察到显着差异，这表明降解产物对肝细胞的功能或活性没有不利影响。培养的细胞。对植入大鼠体内的预制乳酸网络的组织反应包括轻度的炎症反应以及纤维囊厚度的增加，而炎症与聚合物降解速度更快相关。这种相对中性的反应表明具有潜在医学应用的生物相容性，可降解聚合物。最后，将多孔支架皮下植入大鼠中，血管化纤维组织的浸润高度依赖于支架的孔隙率和结构。该发现表明该组合物的原位形成的多孔支架可支持周围血管化组织的浸润，因此可应用于大骨缺损的整形外科治疗。

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