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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >The Effect of Structural Characteristics on the In Vitro Bioactivity of Hydroxyapatite
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The Effect of Structural Characteristics on the In Vitro Bioactivity of Hydroxyapatite

机译：结构特征对羟基磷灰石体外生物活性的影响

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摘要

In previous studies a film of hydroxylapatite (HA) was coated onto the inner pore surfaces of reticulated alumina for bone substitutes with the use of a so-called thermal deposition method. In this process, the HA films must be sintered at high temperatures for a strong adhesion to the alumina substrate. It has been found that high-temperature sintering inevitably changes the crystallinity of the coated HA, and in turn affects its bioactivity. Therefore, in this study, in vitro experiments were carried out to investigate the effects of structural changes on the in vitro bioactivity. The factors dominating in vitro bioactivity of HA, including surface area, degree of crystallinity, and temperature, were identified. The activation energy for volume diffusion was calculated for different in vitro solution temperatures. Also discussed is the underlying mechanism of growth and dissolution processes during the in vitro test.
机译：在先前的研究中，使用所谓的热沉积方法将羟基磷灰石（HA）膜涂覆在网状氧化铝的内孔表面上，以替代骨。在此过程中，必须在高温下烧结HA膜，以牢固粘附到氧化铝基材上。已经发现，高温烧结不可避免地改变了涂覆的HA的结晶度，进而影响了其生物活性。因此，在这项研究中，进行了体外实验以研究结构变化对体外生物活性的影响。确定了影响HA体外生物活性的因素，包括表面积，结晶度和温度。针对不同的体外溶液温度计算了体积扩散的活化能。还讨论了体外测试过程中生长和溶解过程的潜在机制。

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