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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Effects of titanium-dental restorative alloy galvanic couples on cultured cells.
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Effects of titanium-dental restorative alloy galvanic couples on cultured cells.

机译：钛-齿修复合金电偶对培养细胞的影响。

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The potential exists for titanium and amalgams to become galvanically coupled in the oral cavity. While low galvanic corrosion rates have been measured in vivo for titanium-amalgam or mercury-free alloy couples, concerns exist over released corrosion products and adverse tissue responses. It was hypothesized in this study that coupling titanium to amalgams or gallium alloys increased the release of metallic corrosion products and decreased cellular activity and function. The effects of titanium coupled and uncoupled to a conventional amalgam, palladium-enriched spherical high copper amalgam, a dispersed type high copper amalgam, and a mercury-free gallium alloy were evaluated in 24-h cell culture tests. Viability, proliferation, and collagen synthesis were evaluated by the uptake of neutral red, 3H-thymidine, and immunoassay of procollagen, respectively, and compared to cells not exposed to any test material. The gallium alloy-titanium couple resulted in significant decreases in cellular viability, proliferation, and collagen synthesis as compared to the other coupled and uncoupled samples. Few differences in the cellular responses of the other coupled and uncoupled samples were observed. Atomic absorption analyses indicated increased release of metal ions from the amalgam and gallium alloy samples coupled to titanium as compared to their uncoupled condition, although the differences were not always significant. Galvanic corrosion of amalgam-titanium couples in the long term may become significant, and further research is needed. Coupling the gallium alloy to titanium may result in increased galvanic corrosion and cytotoxic responses.
机译：钛和汞齐在口腔中电耦合存在潜力。尽管已对钛汞齐或无汞合金对进行了体内低电腐蚀速率的测试，但人们对释放出的腐蚀产物和不良的组织反应仍然存在担忧。在这项研究中假设将钛与汞齐或镓合金偶联会增加金属腐蚀产物的释放并降低细胞活性和功能。在24小时的细胞培养测试中，评估了钛与常规汞齐，富钯的球形高铜汞齐，分散型高铜汞齐和无汞镓合金的耦合和解耦作用。分别通过中性红，3H-胸苷的摄取和原胶原的免疫测定来评估活力，增殖和胶原蛋白的合成，并与未暴露于任何测试材料的细胞进行比较。与其他偶联和未偶联的样品相比，镓合金-钛偶联导致细胞活力，增殖和胶原蛋白合成显着降低。观察到其他偶联和未偶联样品的细胞反应几乎没有差异。原子吸收分析表明，与未偶联条件相比，与钛偶联的汞合金和镓合金样品中金属离子的释放增加，尽管差异并不总是很明显。从长期来看，汞合金-钛对的电偶腐蚀可能会变得很重要，需要进一步的研究。镓合金与钛的偶联可能导致电腐蚀和细胞毒性反应增加。

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