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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Thermal analysis of bones from ovariectomized rats.
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Thermal analysis of bones from ovariectomized rats.

机译：去卵巢大鼠骨骼的热分析。

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摘要

Thermal analyses [thermogravimetry (TG) and differential thermal analysis (DTA)], X-ray diffraction, and infrared absorption analysis of bones from ovariectomized rats were carried out. The rats were divided into five groups: sham operated (Sham); ovariectomized (OVX); OVX given traditional Chinese (Kampo) medicine, Unkei-to; OVX given 17 beta-estradiol; and OVX given the estradiol vehicle, respectively. The activation energy (delta E), a kinetic parameter from TG data of OVX rats, increased by 57% from that in Sham rats. The administration of Unkei-to and 17 beta-estradiol to OVX rats clearly restored the delta E to the levels of Sham rats, while the vehicle for 17 beta-estradiol had no effect. DTA data from thermal analyses of rats from the Sham, OVX, and OVX given various compounds were almost the same except for OVX rats given 17 beta-estradiol. The X-ray diffraction pattern and infrared absorption spectrum of bone powders from Sham rats were not different from those of OVX rats or others. These results strongly suggest that kinetic parameter, delta E calculated from TG data, may be a useful method for assessing both experimentally induced osteoporosis and drug effects on it.
机译：进行了去卵巢大鼠骨骼的热分析[热重法（TG）和差热分析（​​DTA）]，X射线衍射和红外吸收分析。将大鼠分为五组：假手术组（Sham）;假手术组（Sham）。去卵巢（OVX）; OVX给予中药（Kampo）， OVX给予17β-雌二醇;和OVX分别给予雌二醇载体。活化能（δE）是OVX大鼠的TG数据的动力学参数，与Sham大鼠相比增加了57％。向OVX大鼠施用Unkei-to和17β-雌二醇可将δE明显恢复至Sham大鼠水平，而17β-雌二醇的赋形剂则无作用。在给定各种化合物的情况下，对来自Sham，OVX和OVX的大鼠进行热分析得到的DTA数据几乎相同，除了OVX给予17β-雌二醇的大鼠。 Sham大鼠的骨粉的X射线衍射图和红外吸收光谱与OVX大鼠或其他OVX大鼠无差异。这些结果强烈表明，从TG数据计算得出的动力学参数δE，可能是评估实验性骨质疏松症及其药物作用的有用方法。

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