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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Cell adhesion peptides alter smooth muscle cell adhesion, proliferation, migration, and matrix protein synthesis on modified surfaces and in polymer scaffolds
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Cell adhesion peptides alter smooth muscle cell adhesion, proliferation, migration, and matrix protein synthesis on modified surfaces and in polymer scaffolds

机译：细胞粘附肽改变修饰表面和聚合物支架中平滑肌细胞的粘附，增殖，迁移和基质蛋白合成

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摘要

The effects of cell adhesion peptides (RGDS, KQAGDV, VAPG) on vascular smooth muscle cells grown on modified surfaces and in tissue-engineering scaffolds were examined. Cells were more strongly adhered to surfaces modified with adhesive ligands than to control surfaces (no ligand or a nonadhesive ligand). Cell migration was higher on surfaces with 0.2 nmol/cm~2 of adhesive ligand than on control surfaces, but it was lower on surfaces with 2.0 nmol/cm~2 of adhesive ligand than it was on control surfaces. Further, cell proliferation was lower on adhesive surfaces than it was on control surfaces, and it decreased as the ligand density increased. Similarly, in the peptide-grafted hydrogel scaffolds, cell proliferation was lower in scaffolds containing the adhesive peptides than it was in control scaffolds. After 7 days of culture, more collagen per cell was produced in control scaffolds than in scaffolds containing adhesive peptides. In addition, collagen production decreased in the scaffolds as the ligand concentration increased. While modification of a surface or scaffold material with adhesive ligands initially increases cell attachment, it may be necessary to optimize cell adhesion simultaneously with proliferation, migration, and matrix production.
机译：检查了细胞粘附肽（RGDS，KQAGDV，VAPG）对修饰表面和组织工程支架中生长的血管平滑肌细胞的影响。与对照表面（无配体或非粘附性配体）相比，细胞更牢固地粘附于用粘合配体改性的表面。具有0.2 nmol / cm〜2的粘合剂配体的表面的细胞迁移高于对照表面，但具有2.0 nmol / cm〜2的粘合剂配体的表面的细胞迁移低于对照表面。此外，粘附表面上的细胞增殖比对照表面上的细胞增殖低，并且随着配体密度的增加而降低。类似地，在肽移植的水凝胶支架中，含有粘附肽的支架中的细胞增殖比对照支架中的细胞增殖低。培养7天后，与含有粘附肽的支架相比，对照支架中每个细胞产生的胶原蛋白更多。另外，随着配体浓度的增加，支架中的胶原蛋白产生减少。尽管最初用粘合剂配体对表面或支架材料进行修饰会增加细胞附着，但可能有必要在增殖，迁移和基质生产的同时优化细胞粘附。

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