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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Histopathologic reaction of a calcium phosphate cement for alveolar ridge augmentation
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Histopathologic reaction of a calcium phosphate cement for alveolar ridge augmentation

机译：磷酸钙骨水泥对牙槽增生的组织病理学反应

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摘要

The objective of the present study was to evaluate the feasibility of using a calcium phosphate cement (CPC) in the reconstruction of a defective alveolar ridge in conjunction with implant placement. The CPC consisted of an equimolar amount of tetracalcium phosphate and dicalcium phosphate anhydrous. At the beginning of the experiment, all mandibular premolar teeth of mature beagle dogs were extracted. After 1 month of healing, alveolar bone was reduced to make a space for a CPC block that was prefabricated from a CPC mixed with water at a powder/liquid ratio of 5 g/mL. After an additional month, 8-mm long hydroxyapatite-coated titanium implants were placed in such a way that the apical half was embedded into alveolar bone and the coronal half in the preformed CPC block. The dogs were sacrificed and biopsies were obtained at 1, 3, and 6 months after surgery. Sections that included implants were evaluated for integration of the CPC block to the alveolar bone and of the implant to the alveolar bone. Additional sections without the implants served as controls. The results obtained from this study show that the CPC ridge augmentation gradually is replaced by natural bone. Six months after surgery, histopathologic features of the augmentation area were quite similar to those of natural alveolar bone. The coronal half of the implants, previously surrounded by the CPC block, was firmly fixed by natural bone. Therefore, this method may be useful for increasing the height of the alveolar ridge.
机译：本研究的目的是评估结合植入物植入使用磷酸钙水泥（CPC）重建缺损的牙槽的可行性。 CPC由等摩尔量的磷酸四钙和无水磷酸二钙组成。在实验开始时，将成熟的比格犬的所有下颌前磨牙拔除。愈合1个月后，将牙槽骨缩小，以留出一个CPC块的空间，该块由以5 g / mL的粉/液比与水混合的CPC预制而成。再过一个月后，放置8毫米长的羟基磷灰石涂层钛植入物，使根尖的一半嵌入牙槽骨中，冠状的一半嵌入预制的CPC块中。处死狗并在手术后1、3和6个月获得活检。评估包括植入物的切片的CPC块与牙槽骨的整合以及植入物与牙槽骨的整合。没有植入物的其他部分用作对照。从这项研究中获得的结果表明，CPC脊骨逐渐被天然骨替代。手术六个月后，隆突区的组织病理学特征与天然牙槽骨非常相似。植入物的冠状半部以前被CPC块所包围，被天然骨牢固地固定。因此，该方法对于增加牙槽的高度可能是有用的。

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