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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Implanted octacalcium phosphate is more resorbable than #beta#-tricalcium phosphate and hydroxyapatite
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Implanted octacalcium phosphate is more resorbable than #beta#-tricalcium phosphate and hydroxyapatite

机译：植入的磷酸八钙比＃beta＃-磷酸三钙和羟基磷灰石更具吸收性

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摘要

Our previous studies have suggested that synthetic octacalcium phosphate (OCP) could be resorbed and replaced by newly formed bone if implanted in rat skull defects. We hypothesized that the implanted OCP is more resorbable than other commonly used bone graft substitutes of calcium phosphate compounds, such as hydroxyapatite (HA) and #beta#-tricalcium phosphate (#beta#-TCP). To test the hypothesis, the present study was designed to compare histomorphometrically resorption of the implanted OCP, HA, and #beta#-TCP, which were kept in the experimental cranial defect of rats for a long term. A full thickness of standardized trephine defect was made in the rat parietal bone, and the same volume of granules of OCP, HA, and #beta#-TCP were implanted into the defect. Five specimens of each group were fixed 6 months after implantation. The percentage of remaining implants (r-Imp percent) and newly formed bone (n-Bone percent) in the defect was analyzed histomorphometrically. The statistical analysis showed that the r-Imp percent of OCP was significantly lower than that of HA and #beta#-TCP. In contrast, the n-Bone percent of OCP was significantly higher than that of HA and #beta#-TCP. The present study has shown that the implanted OCP in the rat cranial defect is more resorbable than the implanted #beta#-TCP and HA, whereas the implanted OCP enhances bone formation more than the implanted #beta#-TCP and HA.
机译：我们以前的研究表明，如果植入大鼠颅骨缺损中，合成的磷酸八钙（OCP）可以被吸收并被新形成的骨头替代。我们假设植入的OCP比其他常用的磷酸钙化合物的骨移植替代物（例如羟基磷灰石（HA）和＃beta＃-磷酸三钙（＃beta＃-TCP））具有更高的可吸收性。为了验证该假设，本研究旨在比较植入的OCP，HA和＃beta＃-TCP的组织形态学吸收，这些OCP，HA和＃beta＃-TCP长期保存在大鼠的实验性颅骨缺损中。在大鼠顶骨中制作了一个完整厚度的标准曲华碱缺损，并将相同体积的OCP，HA和＃beta＃-TCP颗粒植入缺损中。植入后6个月，每组固定5个标本。组织形态计量学分析了缺损中剩余植入物的百分比（r-Imp百分比）和新形成的骨骼（n-Bone百分比）。统计分析表明，OCP的r-Imp百分比显着低于HA和＃beta＃-TCP的r-Imp百分比。相反，OCP的n-Bone百分比显着高于HA和＃beta＃-TCP。本研究表明，在大鼠颅骨缺损中植入的OCP比植入的＃beta＃-TCP和HA更易于吸收，而植入的OCP比植入的＃beta＃-TCP和HA更能增强骨骼形成。

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