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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Tobramycin and Gentamycin Elution Analysis between Two in Situ Polymerizable Orthopedic Composites
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Tobramycin and Gentamycin Elution Analysis between Two in Situ Polymerizable Orthopedic Composites

机译：两种原位可聚合骨科复合材料之间的妥布霉素和庆大霉素洗脱分析

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This research analyzed Tobramycin and Gentamycin elution characteristics for two antibiotic-impregnated bone composites: PMMA-based Simplex P~R and the novel, hybrid, bioactive, CORTOSS~(TM). Experimental results were correlated with composite hydrophilicity and antibiotic phase partitioning behaviors. The phase partitioning experiment was conducted to understand antibiotic solubility in aqueous environments. By comparing experimental results with calculated data, antibiotic release behavior was predicted. Total Tobramycin elution percentages from CORTOSS and Simplex P were 12.5 and 6.4 percent, respectively. Total Gentamycin elution percentages from CORTOSS and Simplex P were 6.95 and 10.17 percent, respectively. Phase partitioning data indicate 100 percent of Tobramycin remains in aqueous phases, being extremely hydrophilic. This is supported by its calculated theoretical value (log P = - 7.32). Results suggest that Tobramycin elution can be attributed to composite hydrophilicity as well as its high degree of hydrophilicity. Fifteen percent of Gentamycin distributes in hydrophobic phases (log P = -4.22). Despite a lower Gentamycin hydrophilicity, its release was affected by its complexation with polar salts in the leaching buffer, thereby increasing its elution potential, making it appreciably water soluble. CORTOSS is more hydrophilic; therefore the migration of aqueous liquids into the polymer network of CORTOSS facilitates greater antibiotic elution compared with hydrophobic Simplex P.
机译：这项研究分析了两种抗生素浸渍的骨复合物的妥布霉素和庆大霉素的洗脱特性：基于PMMA的Simplex P〜R和新型的，混合的，具有生物活性的CORTOSS〜（TM）。实验结果与复合亲水性和抗生素相分配行为相关。进行相分配实验以了解抗生素在水性环境中的溶解度。通过将实验结果与计算数据进行比较，可以预测抗生素的释放行为。 CORTOSS和Simplex P的总妥布霉素洗脱百分比分别为12.5％和6.4％。 CORTOSS和Simplex P的庆大霉素总洗脱百分率分别为6.95％和10.17％。相分配数据表明妥布霉素100％保留在水相中，具有极高的亲水性。这由其计算的理论值来支持（log P =-7.32）。结果表明妥布霉素的洗脱可以归因于复合亲水性及其高度的亲水性。 15％的庆大霉素分布在疏水相中（log P = -4.22）。尽管庆大霉素的亲水性较低，但其释放仍受到其与浸出缓冲液中极性盐的络合的影响，从而增加了其洗脱潜力，使其明显溶于水。 CORTOSS更亲水;因此，与疏水性Simplex P相比，水性液体向CORTOSS聚合物网络的迁移促进了更大的抗生素洗脱。

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