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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Macrophages at the skeletal tissue-device interface of loosened prosthetic devices express bone-related genes and their products
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Macrophages at the skeletal tissue-device interface of loosened prosthetic devices express bone-related genes and their products

机译：假体松动的骨骼组织-设备界面处的巨噬细胞表达骨相关基因及其产物

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摘要

Aseptic loosening of prosthetic arthroplasty is the most common reason for implant failure in adult orthopaedic reconstruction. At the interface of aseptic loosened prostheses, there is an abundance of particle-activated macrophages and other inflammatory cells. The role of these particle-laden macrophages in the osteogenic arm of the remodeling skeleton in this pathological condition is poorly understood. Molecular signaling by mesenchymal cells and mononuclear inflammatory cells residing in the interfacial tissues between bone and cement or prosthetic material of aseptically loosened joint prostheses was studied using in situ hybridization and immunohistochemical techniques. We found that a range of collagenous and noncollagenous matrix proteins, including osteopontin, osteocalcin, bone sialoprotein, and type I collagen, were produced in the periprosthetic tissue by foamy macrophages, as well as nearby osteogenic cells. The former accumulated in profusion in the three zones of interfacial tissues: pseudomembranous, fibrous, and osseous. Spindle mesenchymal cells in the fibrous zone failed to express any of the osteogenic mRNAs or proteins sought. The expression of bone-related genes and proteins by foamy macrophages at the interface of an aseptic loosened prosthesis may contribute to the disturbance of bone remodeling at this site.
机译：人工关节置换术的无菌性松动是成年骨科重建手术中植入失败的最常见原因。在无菌假体的界面处，有大量的颗粒活化巨噬细胞和其他炎症细胞。在这种病理情况下，这些重负载巨噬细胞在重塑骨架的成骨臂中的作用了解甚少。使用原位杂交和免疫组织化学技术研究了位于无菌连接松动的假体的骨和骨水泥或假体材料之间界面组织中的间充质细胞和单核炎性细胞的分子信号传导。我们发现，泡沫巨噬细胞和附近的成骨细胞在假体周围组织中产生了一系列胶原和非胶原基质蛋白，包括骨桥蛋白，骨钙蛋白，骨唾液蛋白和I型胶原。前者堆积在界面组织的三个区域：假膜，纤维和骨中。纤维区中的纺锤体间充质细胞未能表达所寻求的任何成骨性mRNA或蛋白质。泡沫疏松的假体界面上的泡沫巨噬细胞表达的骨相关基因和蛋白质可能会干扰该部位的骨重塑。

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