...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Frontal Sinus and Skull Bone Defect Obliteration with Three Synthetic Bioactive Materials. A Comparative Study
【24h】

Frontal Sinus and Skull Bone Defect Obliteration with Three Synthetic Bioactive Materials. A Comparative Study

机译：三种合成生物活性材料清除额窦和颅骨缺损。比较研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Three synthetic bioactive materials were studied in an experimental model to compare their usability in a frontal sinus and a skull bone defect obliteration. Bioactive glass number 9 (BAG~1), bioactive glass number 13 (BAG~2), and hydroxyapatite (HA) granules were investigated. BAG~1 and HA granules have been previously tested clinically. The clinical usefulness of BAG~2 granules has not been tested. Upper bony walls of 45 Elco rabbits' frontal sinuses were drilled open from four separate holes with the use of a standard method. The skull bone defects and the sinuses in frontal bone were filled with BAG~1 or BAG~2 on one side, and with HA on the other side. Two parallel posterior defects were covered with a pedicled periosteum flap, and two anterior defects with a free flap. The resorption of materials, new bone, and fibrous-tissue formation were observed with a histomorphometric method at 1, 3, and 6 months postoperatively. Scanning-electron microscopy (SEM) and Fourier-transform infrared spectroscopy (FTIR) were done at 6 months. In histomorphometry, the new bone formation increased with all the investigated materials throughout the study (p < 0.001), but the results showed higher new bone formation in the defects filled with BAG~1 than in corresponding BAG~2- or HA- filled defects. New bone formation and resorption of materials were faster in defects covered by pedicled than by free periosteum flaps (p < 0.001). Intimate contact between the used materials and new bone was confirmed by SEM. FTIR analysis of bone produced by BAG~1 and BAG~2 was of the same type as natural frontal bone. BAG~2 can be manufactured in various shapes, and thus, could possibly be used in clinical conditions requiring a special anatomical implant shape. However, more research is needed regarding this property of BAG.
机译：在实验模型中研究了三种合成生物活性材料，以比较它们在额窦和颅骨缺损中的可用性。研究了9号生物活性玻璃（BAG〜1），13号生物活性玻璃（BAG〜2）和羟基磷灰石（HA）颗粒。 BAG〜1和HA颗粒以前已经过临床测试。 BAG〜2颗粒的临床用途尚未经过测试。使用标准方法，从四个单独的孔中钻出45只Elco兔额窦的上骨壁。颅骨缺损和额骨窦在一侧充满BAG〜1或BAG〜2，在另一侧充满HA。带蒂的骨膜瓣覆盖了两个平行的后部缺损，而游离的皮瓣覆盖了两个前部缺损。术后1、3和6个月，用组织形态测定法观察到材料的吸收，新骨和纤维组织的形成。在六个月时进行了扫描电子显微镜（SEM）和傅里叶变换红外光谱（FTIR）。在组织形态计量学中，在整个研究过程中，所有研究材料的新骨形成均增加（p <0.001），但结果显示，填充BAG〜1的缺损比对应的BAG〜2或HA填充的缺损具有更高的新骨形成。 。带蒂覆盖的缺损中的新骨形成和材料的吸收要快于游离骨膜瓣（p <0.001）。 SEM证实了所用材料与新骨之间的紧密接触。 BAG〜1和BAG〜2产生的骨骼的FTIR分析与天然额骨相同。 BAG_2可以制成各种形状，因此可以用于需要特殊解剖植入物形状的临床条件。但是，关于BAG的这一特性，需要进行更多的研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号