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首页> 外文期刊>Journal of biomedical materials research, Part A >Effect of weight-bearing on bone-bonding behavior of strontium-containing hydroxyapatite bone cement
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Effect of weight-bearing on bone-bonding behavior of strontium-containing hydroxyapatite bone cement

机译:承重对含锶羟基磷灰石骨水泥骨结合行为的影响

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摘要

The purpose of this study was to investigate and compare the chemical composition and nanomechanical properties at the bone-cement interface under non-weight-bearing and weight-bearing conditions, in order to understand the effect of weight-bearing on the bone-bonding behavior of strontium-containing hydroxyapatite (Sr-HA) cement. In one group, Sr-HA cement was injected into rabbit ilium (under non-weight-bearing conditions). Unilateral hip replacement was performed with Sr-HA cement (under weight-bearing conditions) in the other group. Six months later, scanning electron microscopy (SEM) with energy-dispersive X-ray (EDX) analysis and nanoindentation tests were conducted on the interfaces between cancellous bone and the Sr-HA cement. The nanoindentation results revealed two different transitional behaviors under different conditions. nder weight-bearing conditions, both the Young modulus and hardness at the interface were considerably higher than those at either the Sr-HA cement or cancellous bone. On the contrary, under non-weight-bearing conditions, both the Young modulus and hardness values at the interface were lower than those at the cancellous bone, but were higher than the Sr-HA cement. In addition, EDX results showed that the calcium and phosphorus contents at the interface under weight-bearing conditions were considerably higher than those under non-weight-bearing conditions. The differences in chemical composition and nanomechanical properties at the cement-bone interface under two different conditions indicate that weight-bearing produces significant effects on the bone-bonding behavior of the Sr-HA cement.
机译:本研究的目的是研究和比较非承重和承重条件下骨水泥界面的化学成分和纳米力学性能,以了解承重对骨粘合行为的影响。含锶的羟基磷灰石(Sr-HA)水泥的生产。在一组中,将Sr-HA水泥注射到兔i骨中(在非负重条件下)。在另一组中,Sr-HA水泥(在负重条件下)进行单侧髋关节置换。六个月后,对松质骨与Sr-HA水泥之间的界面进行了扫描电子显微镜(SEM)和能量色散X射线(EDX)分析和纳米压痕测试。纳米压痕结果揭示了在不同条件下的两种不同的过渡行为。在承重条件下,界面处的杨氏模量和硬度均明显高于Sr-HA骨水泥或松质骨。相反,在非承重条件下,界面处的杨氏模量和硬度值均低于松质骨,但高于Sr-HA水泥。另外,EDX结果表明,在负重条件下界面的钙和磷含量明显高于非负重条件下的界面。在两种不同条件下,水泥-骨界面的化学成分和纳米力学性能的差异表明,承重对Sr-HA水泥的骨结合行为产生重大影响。

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