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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >In vitro analysis of biodegradable polymer blend/hydroxyapatite composites for bone tissue engineering.
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In vitro analysis of biodegradable polymer blend/hydroxyapatite composites for bone tissue engineering.

机译：用于骨组织工程的可生物降解的聚合物共混物/羟基磷灰石复合材料的体外分析。

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摘要

Blends of biodegradable polymers, poly(caprolactone) and poly(D, L-lactic-co-glycolic acid), have been examined as scaffolds for applications in bone tissue engineering. Hydroxyapatite granules have been incorporated into the blends and porous discs were prepared. Mechanical properties and degradation rates in vitro of the composites were determined. The discs were seeded with rabbit bone marrow or cultured bone marrow stromal cells and incubated under physiological conditions. Polymer/ceramic scaffolds supported cell growth throughout the scaffold for 8 weeks. Scanning and transmission electron microscopy, and histological analyses were used to characterize the seeded composites. This study suggests the feasibility of using novel polymer/ceramic composites as scaffold in bone tissue engineering applications. Copyright 1999 John Wiley & Sons, Inc.
机译：已经研究了可生物降解的聚合物，聚己内酯和聚D，L-乳酸-共-乙醇酸的共混物，作为在骨组织工程中应用的支架。将羟基磷灰石颗粒掺入到混合物中并制备了多孔盘。测定了复合材料的机械性能和体外降解速率。将圆盘接种兔骨髓或培养的骨髓基质细胞，并在生理条件下孵育。聚合物/陶瓷支架在整个支架中支持细胞生长8周。扫描和透射电子显微镜以及组织学分析被用来表征种子复合材料。这项研究表明在骨组织工程应用中使用新型聚合物/陶瓷复合材料作为支架的可行性。版权所有1999 John Wiley＆Sons，Inc.

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