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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >The influence of polymeric component of bioactive glass-based nanocomposite paste on its rheological behaviors and in vitro responses: Hyaluronic acid versus sodium alginate
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The influence of polymeric component of bioactive glass-based nanocomposite paste on its rheological behaviors and in vitro responses: Hyaluronic acid versus sodium alginate

机译：生物活性玻璃基纳米复合材料糊剂的聚合物组分对其流变行为和体外响应的影响：透明质酸与海藻酸钠

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Different biocomposite pastes were prepared from a solid phase that was nanoparticles of sol-gel-derived bioactive glass and different liquid phases including 3% hyaluronic acid solution, sodium alginate solutions (3% and 10 %) or mixtures of hyaluronic acid and sodium alginate (3% or 10 %) solutions in 50:50 volume ratio. Rheological properties of the pastes were measured in both rotatory and oscillatory modes. The washout behavior and in vitro apatite formation of the pastes were determined by soaking them in simulated body fluid under dynamic situation for 14 days. The proliferation and alkaline phosphatase activity of MG-63 osteoblastic cells were also determined using extracts of the pastes. All pastes could be easily injected from the standard syringes with different tip diameters. All pastes exhibited visco-elastic character, but a nonthixotropic paste was obtained using hyaluronic acid in which the loss modulus was higher than the storage modulus. The thixotropy and storage modulus were increasingly improved by adding/using sodium alginate as mixing liquid. Moreover, the pastes in which the liquid phase was sodium alginate or mixture of hyaluronic acid and 10% sodium alginate solution revealed better apatite formation ability and washout resistance than that made of hyaluronic acid alone. No cytotoxicity effects were observed by extracts of the pastes on osteoblasts but better alkaline phosphatase activity was found for the pastes containing hyaluronic acid. Overall, injectable biocomposites can be produced by mixing bioactive glass nanoparticles and sodium alginate/hyaluronic acid polymers. They are potentially useful for hard and even soft tissues treatments.
机译：由固相制备不同的生物复合糊剂，固相是溶胶-凝胶衍生的生物活性玻璃的纳米颗粒，液相包括3％的透明质酸溶液，海藻酸钠溶液（3％和10％）或透明质酸和海藻酸钠的混合物（体积比为50:50的3％或10％）溶液。在旋转和振荡模式下都测量了糊的流变性质。通过在动态情况下将其浸泡在模拟体液中14天，确定糊料的洗脱行为和体外磷灰石形成。 MG-63成骨细胞的增殖和碱性磷酸酶活性也使用糊剂提取物进行测定。所有糊剂都可以轻松地从具有不同尖端直径的标准注射器中注入。所有糊剂均表现出粘弹性，但是使用透明质酸获得了非触变性糊剂，其中损失模量高于储能模量。通过添加/使用海藻酸钠作为混合液，触变性和储能模量逐渐提高。此外，液相为藻酸钠或透明质酸与10％藻酸钠溶液的混合物的糊剂比仅由透明质酸制成的糊剂具有更好的磷灰石形成能力和耐洗出性。糊剂的提取物未观察到对成骨细胞的细胞毒性作用，但发现含有透明质酸的糊剂具有更好的碱性磷酸酶活性。总体而言，可通过将生物活性玻璃纳米颗粒与藻酸钠/透明质酸聚合物混合来制备可注射的生物复合材料。它们可能对硬组织甚至软组织治疗有用。

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