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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Biocompatibility and tissue integration of a novel shape memory surgical mesh for ventral hernia: In vivo animal studies
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Biocompatibility and tissue integration of a novel shape memory surgical mesh for ventral hernia: In vivo animal studies

机译：用于腹疝的新型形状记忆外科网片的生物相容性和组织整合：体内动物研究

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摘要

Approximately 400,000 ventral hernia repair surgeries are performed each year in the United States. Many of these procedures are performed using laparoscopic minimally invasive techniques and employ the use of surgical mesh. The use of surgical mesh has been shown to reduce recurrence rates compared to standard suture repairs. The placement of surgical mesh in a ventral hernia repair procedure can be challenging, and may even complicate the procedure. Others have attempted to provide commercial solutions to the problems of mesh placement, but these have not been well accepted by the clinical community. In this article, two versions of shape memory polymer (SMP)-modified surgical mesh, and unmodified surgical mesh, were compared by performing laparoscopic manipulation in an acute porcine model. Also, SMP-integrated polyester surgical meshes were implanted in four rats for 30-33 days to evaluate chronic biocompatibility and capacity for tissue integration. Porcine results show that the modified mesh provides a controlled, temperature-activated, automated deployment when compared to an unmodified mesh. In rats, results indicate that implanted SMP-modified meshes exhibit exceptional biocompatibility and excellent integration with surrounding tissue with no noticeable differences from the unmodified counterpart. This article provides further evidence that an SMP-modified surgical mesh promises reduction in surgical placement time and that such a mesh is not substantially different from unmodified meshes in chronic biocompatibility.
机译：在美国，每年大约进行40万例腹侧疝修补手术。这些程序中有许多是使用腹腔镜微创技术进行的，并采用了手术网片。与标准的缝线修复相比，使用外科网片已显示降低了复发率。在腹疝修补术中放置外科手术网可能具有挑战性，甚至可能使手术复杂化。其他人试图为网格放置问题提供商业解决方案，但是这些尚未被临床界很好接受。在本文中，通过在急性猪模型中进行腹腔镜操作，比较了两种版本的形状记忆聚合物（SMP）修饰的手术网和未修饰的手术网。另外，将整合了SMP的聚酯外科手术网植入四只大鼠中30-33天，以评估其慢性生物相容性和组织整合能力。猪的结果表明，与未修改的网格相比，修改后的网格可提供受控的，温度激活的自动部署。在大鼠中，结果表明，植入的SMP修饰的网片具有出色的生物相容性，并且与周围组织的融合性极佳，与未修饰的对应物没有明显的区别。本文提供了进一步的证据，表明经过SMP修饰的手术网片有望减少手术放置时间，并且这种网片与未修饰的网片在慢性生物相容性方面基本没有不同。

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