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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Prophylaxis of implant-related staphylococcal infections using tobramycin-containing bone cement
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Prophylaxis of implant-related staphylococcal infections using tobramycin-containing bone cement

机译：使用含妥布霉素的骨水泥预防与植入物有关的葡萄球菌感染

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摘要

In a rabbit model, premixed tobramycin-containing bone cement was studied for its efficacy to prevent infections with two frequently encountered staphylococcal species in arthroplasty surgery. After intramedullary inoculation with staphylococci, either standard or premixed tobramycin-containing Simplex-P bone cement was injected in the right femur of 120 rabbits. Development of infection was examined by culture of femoral bone after 7 or 28 days. Loss of body weight and elevated erythrocyte sedimentation rate in the control rabbits inoculated with Staphylococcus aureus were seen in the first postoperative week, returning to normal in 28 days. Inoculation with Staphylococcus epidermidis resulted only in a low-grade infection. AU rabbits receiving premixed tobramycin-containing bone cement were free of signs of infection, and all their cultures were negative. Culture yield from Staphylococcus aureus controls increased with time and inoculum dose. Staphylococcus epidermidis con-trols needed higher inoculum doses to establish an infection, while culture yield decreased in time. These differences in mode of prosthesis-related infection are explained by differences in virulence factors.
机译：在兔模型中，研究了预混合的含妥布霉素的骨水泥在关节成形术中预防两种常见葡萄球菌感染的功效。在髓内接种葡萄球菌后，将标准或预混合的含妥布霉素的Simplex-P骨水泥注入120只兔的右股骨中。 7或28天后通过股骨培养检查感染的发展。在术后第一周观察到接种金黄色葡萄球菌的对照兔的体重减轻和红细胞沉降率升高，在28天内恢复正常。表皮葡萄球菌的接种仅导致低度感染。所有接受含妥布霉素预混骨水泥的兔子均无感染迹象，所有培养均为阴性。金黄色葡萄球菌对照的培养物产量随时间和接种剂量的增加而增加。表皮葡萄球菌控制需要更高的接种剂量以建立感染，而培养物产量随时间下降。假体相关感染方式的这些差异由毒力因子的差异解释。

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