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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Laboratory-Scale Mass Production of a Multi-Micropatterned Grafted Surface with Different Polymer Regions
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Laboratory-Scale Mass Production of a Multi-Micropatterned Grafted Surface with Different Polymer Regions

机译：具有不同聚合物区域的多微图案接枝表面的实验室规模批量生产

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In this article, we demonstrate laboratory-scale mass production of a regionally precise multi-micropatterned surface photo-graft-copolymerized with three water-soluble monomers based on the photochemistry of an iniferter, which means that it acts as an initiator, a transfer agent and a terminator, benzyl N,N-diethvldithiocarbamate. The surface was semi-automatically prepared using a combination of a custom-designed irradiation apparatus installed with a motor-controlled stage for a substrate and three photomasks with different line-patterned slits (number of slits 20, width 500 #mu#m, length 10 mm), and carbon dioxide laser cutting apparatus. A particular region of poly(styrene-co-vinylbenzyl N,N-diethyldithiocar-bamate) coated on a PET film was irradiated in a particular aqueous monomer solution while moving the irradiated portion stepwise after irradiation through each line of the photomask. Photo-graft-copolymerization was carried out sequentially with acrylic acid sodium salt (AANa), N-(3-(daimetaviamino propyl) acryiamiue metnionine (DMAPAAm), and acrylamide (AAm) using differently patterned photomasks. Characterization of surface elemental distribution by X-ray photoelectron spectroscopy (XPS), and light microscopic visualization by dye staining revealed a microprocessed surface with 20 sets of micropatterns, each of which had three line regions grafted with three different polymers. The irradiation of a carbon dioxide laser manipulated via computer-aided design (CAD) software onto the microprocessed surface resulted in automatic circular cutting for each set of micropatterns to mass-produce multimicropatterned substrates for the study of substrate-dependent endothelial cell responses.
机译：在本文中，我们证明了基于引发剂的光化学性质，在实验室范围内批量生产与三种水溶性单体共聚的区域精确的多微图案化表面光接枝，这意味着它可以充当引发剂，转移剂和终止子，苄基N，N-二乙烯基二硫代氨基甲酸酯。使用安装有用于基板的电机控制台的定制设计的辐照设备和具有不同线条图案化缝隙的三个光掩模（缝隙的数量为20，宽度为500＃μm，长度为30）的组合，对表面进行半自动制备。 10毫米）和二氧化碳激光切割设备。在通过光掩模的每条线照射之后逐步地移动被照射的部分的同时，在特定的单体水溶液中照射涂覆在PET膜上的聚（苯乙烯-共乙烯基苄基N，N-二乙基二硫代氨基甲酸酯）的特定区域。使用不同图案的光掩膜，先后与丙烯酸钠盐（AANa），N-（3-（大丁氨基氨基丙基）丙烯酰胺甲氨酸（DMAPAAm）和丙烯酰胺（AAm）进行光接枝共聚。射线光电子能谱（XPS）以及通过染料染色的光学显微镜观察显示了具有20组微图案的微加工表面，每个微图案具有三个接枝有三种不同聚合物的线区域，并通过计算机辅助操作的二氧化碳激光的辐照设计（CAD）到微处理过的表面上的软件导致了每组微图案的自动圆形切割，从而大量生产了多微图案的底物，用于研究底物依赖性内皮细胞的反应。

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