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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Production of porous hydroxyapatite by gel-casting foams and cytotoxic evaluation
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Production of porous hydroxyapatite by gel-casting foams and cytotoxic evaluation

机译：凝胶铸造泡沫生产多孔羟基磷灰石及细胞毒性评估

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This study presents the manufacture ofhighly porous hydroxyapatite by a novel technique thatemploys the foaming of suspensions prior to the in situpolymerization of organic monomers contained in thecompositions. m's method produces strong gelledbodies with up to 90% porosity that can withstandmachining in the green state. Complex-shapedcomponents can be obtained if the process comprisescasting in one of the processing steps. The organicadditives are eliminated at temperatures above 300 degC, and sintering is carried out for consolidation ofthe ceramic matrix Spherical interconnected cellswith sizes ranging from 20 to 1000 #mu#m characterizethe porous structure, depending on the specimendensity. Cytotoxicity tests were conducted onextracts from sintered HA foams based on aquantitative method of cell colony formation and thedetermination of cell death after indirect contact ofthe porous material with mammalian cells. This invitro test of biological evaluation revealed that theoriginal purity of the biomedical-grade hy-droxyapatite powder was affected neither throughprocessing nor by the employed reagents.
机译：这项研究提出了一种高孔隙率的羟基磷灰石的制造方法，该技术在将组合物中所含的有机单体进行原位聚合之前，先将悬浮液发泡。 m的方法生产出坚固的凝胶体，其孔隙率高达90％，可以在绿色状态下进行机械加工。如果该方法包括在其中一个处理步骤中进行浇铸，则可以获得复杂形状的组件。在高于300摄氏度的温度下会除去有机添加剂，并进行烧结以固结陶瓷基体。取决于样品的密度，球形互连单元的尺寸在20到1000＃μm之间，是多孔结构的特征。基于多孔菌体与哺乳动物细胞间接接触后细胞集落形成的定量方法和确定细胞死亡的测定方法，从烧结的HA泡沫中进行了细胞毒性试验。这项生物学评估的体外测试表明，生物医学级羟基磷灰石粉的原始纯度既不受加工工艺的影响，也不受所用试剂的影响。

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