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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Comparison of the Biomechanics and Histology of Two Soft-Tissue Fixators Composed of Bioabsorbable Composed of Bioabsorbable Copolymers
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Comparison of the Biomechanics and Histology of Two Soft-Tissue Fixators Composed of Bioabsorbable Composed of Bioabsorbable Copolymers

机译：两种由生物可吸收共聚物组成的软组织固定器的生物力学和组织学比较

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The purpose of this study was to assess the dynamic in vitro and in vivo characteristics of two different bioabsorbable copolymer soft-tissue fixation devices and to determine their efficacy in reattaching soft tissue to bone. Suretac fixators (Smith & Nephew/Acufex MicroSurgical Inc., Northwood, MA:), made of polyglyconate (2:1 glycolic acid: trimethylene carbonate), and Pop Rivets (Arthrotek, Warsaw, IN), made of LactoSorb (82 percent poly L-lactic acid, 18 percent polyglycolic acid), were anchored into synthetic bone, and their pull-out strengths were evaluated. The devices were also evaluated with the use of an in vivo goat model in which the medial collateral ligament (MCL) was elevated from the tibia and directly reattached. In the in vitro biomechanical study, the Suretac fixators had negligible strength remaining by four weeks, whereas the Pop Rivets retained 50 percent of their strength at 4 weeks, 20 percent at 8 weeks, and negligible strength at 12 weeks. The in vivo strength of MCL repairs affected by each implant was not statistically different at any of the time points. Histologically, both implants were absorbed by 52 weeks, and there was no appreciable adverse tissue response. In conclusion, both copolymer fixators were found to be biocompatible. The Pop Rivet fixators demonstrated in vivo performance comparable to the Suretac fixators, although the Pop Rivets retained strength longer in vitro. Our results suggest that both devices provide adequate strength of fixation before degrading to allow the healing soft tissues to reach or surpass their native strength.
机译：这项研究的目的是评估两种不同的生物可吸收共聚物软组织固定装置的动态体外和体内特性，并确定它们在将软组织重新附着于骨骼上的功效。 Suretac固定剂（Smith和Nephew / Acufex MicroSurgical Inc.，马萨诸塞州诺斯伍德）由聚甘油酸酯（2：1乙醇酸：碳酸三亚甲基酯）制成，而Pop Rivets（Arthrotek，华沙，印第安纳州）制成，由LactoSorb（聚脂含量为82％）制成将L-乳酸（18％的聚乙醇酸）固定在合成骨中，并评估其抗拉强度。还使用体内山羊模型对设备进行了评估，在该模型中，内侧副韧带（MCL）从胫骨中抬起并直接重新连接。在体外生物力学研究中，Suretac固定剂的剩余强度可以忽略不计四周，而Pop Rivets的固定强度在4周时保持50％，在8周时保持20％，在12周时强度可以忽略不计。在任何时间点，受每种植入物影响的MCL修复的体内强度在统计学上均无差异。从组织学上看，两个植入物都吸收了52周，并且没有明显的不良组织反应。总之，发现两种共聚物固定剂都是生物相容的。尽管Pop Rivets保留了更长的体外强度，但其在体内的性能却与Suretac固定剂相当。我们的结果表明，两种器械在降解前均提供足够的固定强度，以使愈合的软组织达到或超过其天然强度。

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