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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Competitive plasma protein adsorption onto fluorinated polyimide surfaces
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Competitive plasma protein adsorption onto fluorinated polyimide surfaces

机译：竞争性血浆蛋白吸附在氟化聚酰亚胺表面上

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摘要

A series of fluorinated polyimides cured at different temperatures was prepared, and plasma protein adsorption and platelet adhesion onto the polyimide films were evaluated in vitro using scanning electron microscopy, a micro-bicinchoninic acid protein assay, and a gold-colloid-labeled immunoassay. In particular, we focused on competitive plasma protein adsorption onto polyimide film because elucidation of the competitive adsorption mechanism is needed for a good understanding of in viva biocompatibility of polyimide. Interestingly, the trend of IgG adsorption onto the polyimide surface measured in human plasma was completely contrary to that observed with IgG dissolved in PBS, and the adsorption increased with an increase in the curing temperature. We propose that the human plasma F region in IgG might selectively adsorb onto polyimide film cured at high temperatures because of competitive plasma protein adsorption to the surface.
机译：制备了一系列在不同温度下固化的氟化聚酰亚胺，并使用扫描电子显微镜，微二辛可宁酸蛋白测定和金胶体标记免疫测定法体外评估了血浆蛋白在聚酰亚胺膜上的吸附和血小板粘附。尤其是，我们专注于竞争性血浆蛋白在聚酰亚胺薄膜上的吸附，因为需要阐​​明竞争性吸附机理才能更好地了解聚酰亚胺的体内生物相容性。有趣的是，在人血浆中测得的IgG在聚酰亚胺表面上的吸附趋势与在PBS中溶解IgG所观察到的趋势完全相反，并且吸附随着固化温度的升高而增加。我们提出，由于血浆中竞争性血浆蛋白的吸附，IgG中的人体血浆F区可能选择性吸附到高温固化的聚酰亚胺薄膜上。

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