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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Osteoblast function on nanophase alumina materials: Influence of chemistry, phase, and topography
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Osteoblast function on nanophase alumina materials: Influence of chemistry, phase, and topography

机译：成骨细胞在纳米氧化铝材料上的功能：化学，相和形貌的影响

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摘要

Alumina is a material that has been used in both dental and orthopedic applications. It is with these uses in mind that osteoblast (bone-forming cell) function on alumina of varying particulate size, chemistry, and phase was tested in order to determine what formulation might be the most beneficial for bone regeneration. Specifically, in vitro osteoblast adhesion, proliferation, intracellular alkaline phosphatase activity, and calcium deposition was observed on delta-phase nanospherical, alpha-phase conventional spherical, and boehmite nanofiber alumina. Results showed for the first time increased osteoblast functions on the nanofiber alumina. Specifically, a 16 percent increase in osteoblast adhesion over nanophase spherical alumina and a 97 percent increase over conventional spherical alumina were found for nanofiber alumina after 2 h. A 29 percent increase in cell number after 5 days and up to a 57 percent greater amount of calcium was found on the surface of the nanofiber alumina compared with other alumina surfaces. Some of the possible explanations for such enhanced osteoblast behavior on nanofiber alumina may be attributed to chemistry, crystalline phase, and topography. Increased osteoblast function on nanofiber alumina suggests that it may be an ideal material for use in orthopedic and dental applications.
机译：氧化铝是已经在牙科和整形外科应用中使用的材料。牢记这些用途，对成骨细胞（成骨细胞）在不同粒径，化学性质和相态的氧化铝上的功能进行了测试，以确定哪种配方可能最有利于骨骼再生。具体地，在δ相纳米球形，α相常规球形和勃姆石纳米纤维氧化铝上观察到体外成骨细胞粘附，增殖，细胞内碱性磷酸酶活性和钙沉积。结果首次显示了纳米纤维氧化铝上成骨细胞的功能增强。具体而言，发现纳米纤维氧化铝在2小时后的成骨细胞粘附力比纳米相球形氧化铝增加16％，而比常规球形氧化铝增加97％。与其他氧化铝表面相比，纳米纤维氧化铝表面在5天后的细胞数增加了29％，钙含量最多增加了57％。这种在纳米纤维氧化铝上增强成骨细胞行为的可能解释可能归因于化学，结晶相和形貌。纳米纤维氧化铝上成骨细胞功能的增强表明它可能是用于整形外科和牙科应用的理想材料。

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