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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Preparation and magnetic resonance imaging effect of polyvinylpyrrolidone-coated iron oxide nanoparticles.
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Preparation and magnetic resonance imaging effect of polyvinylpyrrolidone-coated iron oxide nanoparticles.

机译：聚乙烯吡咯烷酮包覆的氧化铁纳米粒子的制备及磁共振成像效果。

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摘要

Polyvinylpyrrolidone (PVP)-coated iron oxide nanoparticles were prepared by the thermal decomposition of Fe(CO)(5) (iron pentacarbonyl) in one step. X-ray diffraction (XRD), transmission electron microscopy (TEM), electrophoretic light scattering (ELS), infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) together with the variation of the molar ratio of PVP/Fe(CO)(5), solvent, and molecular weight of PVP, were used to characterize the PVP-coated iron oxide nanoparticles. Fifty to hundred nanometer-sized iron oxide nanoclusters with a spherical shape were formed in dimethylformamide (DMF), used as a solvent, and exhibited an enhanced stability in the aqueous media. Their magnetic properties were investigated by superconducting quantum interface device (SQUID). The in vitro cytotoxicity test revealed that the PVP-coated iron oxide nanoparticles exhibited excellent biocompatibility by MTT assay. Magnetic resonance imaging (MRI) effect was observed with the administration of PVP-coated iron oxide nanoparticles through the marginal vein of rabbit, resulting in improved detection of the liver lesions.
机译：聚乙烯吡咯烷酮（PVP）包覆的氧化铁纳米粒子是通过一步一步分解Fe（CO）（5）（五羰基铁）制备的。 X射线衍射（XRD），透射电子显微镜（TEM），电泳光散射（ELS），红外光谱（FTIR）和X射线光电子能谱（XPS）以及PVP / Fe（CO）摩尔比的变化（5），溶剂和PVP的分子量用于表征PVP包覆的氧化铁纳米颗粒。在二甲基甲酰胺（DMF）中形成了球形的五十到一百个纳米尺寸的氧化铁纳米簇，用作溶剂，并且在水性介质中表现出增强的稳定性。通过超导量子接口装置（SQUID）研究了它们的磁性。体外细胞毒性测试显示，通过MTT分析，PVP包覆的氧化铁纳米颗粒表现出优异的生物相容性。通过兔边缘静脉施用PVP涂层的氧化铁纳米颗粒可观察到磁共振成像（MRI）效果，从而改善了对肝脏病变的检测。

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