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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Effect of bioactive filler content on mechanical properties and osteoconductivity of bioactive bond cement
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Effect of bioactive filler content on mechanical properties and osteoconductivity of bioactive bond cement

机译：生物活性填料含量对生物活性粘结水泥力学性能和骨导性的影响

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We took three types of bioactive bone cement (designated AWC, HAC, and TCPC), each with a different bioactive filler, and evaluated the influence of each filler on the mechanical properties and osteoconductivity of the cement. The cements consisted of bisphenol-a-glycidyl methacrylate-based (Bis-GMA based) monomers as an organic matrix, with a bioactive filler of apatite/wollastonite containing glass-ceramic (AW-GC) or sintered hydroxyapatite (HA) or #beta#-tricalcium phosphate (#beta#-TCP) powder. Each filler was mixed with the monomers in proportions of 50,70, and 80 percent (w/w), giving a total of nine cement subgroups. The nine subgroups were designated AWC50, AWC70, AWC80, HAC50, HAC70, HAC80, TCPC50, TCPC70, and TCPC80. The compressive and bending strengths of AWC were found to be higher than those of HAC and TCPC for all bioactive filler contents. We also evaluated the cements in vivo by packing them into the intramedullary canals of rat tibiae. To compare the osteoconductivity of the cements, an affinity index was calculated for each cement; it equaled the length of bone in direct apposition to the cement, expressed as a percentage of the total length of the cement surface. Micro-radiographic examination up to 26 weeks after implantation revealed that AWC showed a higher affinity index than HAC and TCPC for each filler content although the affinity indices of all nine subgroups (especially the AWC and HAC subgroups) increased with time. New bone had formed along the AWC surface within 4 weeks, even in the cement containing AW-GC filler at only 50 percent (w/w); observation of the cement-bone interfaces using a scanning electron microscope showed that all the cements had directly contacted the bone. At 4 weeks the AWC had bonded to the bone via a 10 #mu#m-thick reactive layer; the width of the layer, in which partly degraded AW-GC particles were seen, became slightly thicker with time. On the other hand, in the HAC-and TCPC-implanted tibiae, some particles on the cement surface were surrounded by new bone and partly absorbed or degraded. The results suggest that the stronger bonding between the inorganic filler and the organic matrix in the AWC cements gave them better mechanical properties. The results also indicate that the higher osteoconductivity of AWC was caused by the higher reactivity of the AW-GC powder on the cement surface.
机译：我们采用了三种类型的生物活性骨水泥（分别称为AWC，HAC和TCPC），每种均具有不同的生物活性填料，并评估了每种填料对水泥的机械​​性能和骨传导性的影响。水泥由甲基丙烯酸双酚-a-缩水甘油酯（Bis-GMA基）单体作为有机基质，以及磷灰石/硅灰石的生物活性填料（含玻璃陶瓷（AW-GC）或烧结的羟基磷灰石（HA）或#beta）组成。 ＃-磷酸三钙（＃beta＃-TCP）粉末。将每种填料与单体以50.70和80％（w / w）的比例混合，总共形成9个水泥亚组。将这9个亚组指定为AWC50，AWC70，AWC80，HAC50，HAC70，HAC80，TCPC50，TCPC70和TCPC80。对于所有生物活性填料含量，发现AWC的抗压强度和抗弯强度均高于HAC和TCPC。我们还通过将水泥包装到大鼠胫骨的髓内管中来对水泥进行了体内评估。为了比较骨水泥的骨传导性，计算了每种骨水泥的亲和指数。它等于直接与水泥并置的骨头的长度，以占水泥表面总长度的百分比表示。植入后长达26周的显微射线照相检查显示，尽管所有9个亚组（尤其是AWC和HAC亚组）的亲和力指数均随时间增加，但AWC对每种填充剂含量的亲和力指数均高于HAC和TCPC。即使在仅含有50％（w / w）的AW-GC填料的水泥中，新骨也沿AWC表面形成了四周。使用扫描电子显微镜对骨水泥界面的观察表明，所有骨水泥都直接接触了骨骼。在第4周，AWC通过厚度为10＃μm的反应层粘结到骨骼上;随着时间的流逝，观察到部分降解的AW-GC颗粒的层的宽度变得略厚。另一方面，在植入了HAC和TCPC的胫骨中，水泥表面的一些颗粒被新骨包围，并被部分吸收或降解。结果表明，AWC水泥中无机填料和有机基体之间的牢固结合使它们具有更好的机械性能。结果还表明，AWC的较高的骨传导性是由AW-GC粉末在水泥表面的较高反应性引起的。

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