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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >In Vitro and In Vivo Biocompatibility Testing of Ti-6Al-7Nb alloy with and without Plasma-Sprayed Hydroxyapatite Coating
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In Vitro and In Vivo Biocompatibility Testing of Ti-6Al-7Nb alloy with and without Plasma-Sprayed Hydroxyapatite Coating

机译：带有和不带有等离子喷涂羟基磷灰石涂层的Ti-6Al-7Nb合金的体外和体内生物相容性测试

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摘要

The Ti-6Al-7Nb alloy has been recently developed for biomedical use, particularly for orthopedics and dental applications. Osteosynthesis has been used to analyze biocompatibility and osseoconduction properties. The interaction of the implant with its biological environment, the formation of the implant material/tissue interface, and the long-term success or failure of integration of the implant material/tissue interface, and the long-term success or failure of integration in the human body is strongly connected with the surface properties of the implant device. This study was undertaken to evaluate the processes involved in biological responses of the Ti-6Al-7Nb alloy with and without hydroxyapatite coatings with both in vitro and in vivo tests. The results were analyzed by scanning electron microscopy (SEM) and energy-dispersive x-ray (EDX) microanalysis. The morphology of the in vitro and in vivo testing results with hydroxyapatite coating was similar to those obtained on the uncoated samples. A mineralized extracellular matrix was similar to those obtained on the uncoated samples. A mineralized extracellular matrix was formed on all materials. Observation of the interface between the cell layer and substrata showed the presence of calcium and phosphorous-rich globular deposits associated with collagen fibers on all materials in vitro and in vivo. A higher density of these globular deposits was observed in all samples.
机译：Ti-6Al-7Nb合金最近被开发用于生物医学用途，特别是用于骨科和牙科应用。骨合成已经用于分析生物相容性和骨传导特性。植入物与其生物环境的相互作用，植入物材料/组织界面的形成，植入物材料/组织界面整合的长期成功或失败以及植入物中材料整合的长期成功或失败人体与植入装置的表面特性密切相关。进行了这项研究，以通过体外和体内试验评估含或不含羟基磷灰石涂层的Ti-6Al-7Nb合金的生物学响应过程。通过扫描电子显微镜（SEM）和能量色散X射线（EDX）显微分析对结果进行分析。羟基磷灰石涂层的体外和体内测试结果的形态与未涂层样品的形态相似。矿化的细胞外基质类似于未涂覆样品获得的基质。在所有材料上形成矿化的细胞外基质。对细胞层和基质之间界面的观察表明，在体外和体内所有材料上都存在与胶原纤维相关的富含钙和富含磷的球状沉积物。在所有样品中均观察到较高密度的这些球状沉积物。

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