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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Biological Reactivity of Zirconia-Hydroxyapatite Composites
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Biological Reactivity of Zirconia-Hydroxyapatite Composites

机译：氧化锆-羟基磷灰石复合材料的生物反应性

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摘要

Materials and devices intended for end-use applications as implants and medical devices must be evaluated to determine their biocompatibility potential in contact with physiological systems. The use of standard practices of biological testing provides a reasonable level of confidence concerning the response of a living organism to a given material or device, as well as guidance in selecting the proper procedures to be carried out for the screening of new or modified materials. This article presents results from cytotoxicity assays of cell culture, skin irritation, and acute toxicity by systemic and intracutaneous injections for powders, ceramic bodies, and extract liquids of hydroxyapatite (HA), calcia partially stabilized zirconia (ZO), and two types of zirconia-hydroxyapatite composites (Z4H6 and Z6H4) with potential for future use as orthopedic and dental implants. They indicate that these materials present potential for this type of application because they meet the requirements of the standard practices recommended for evaluating the biological reactivity of ATCC cell cultures (CCL1 NCTC clone 929 of mouse connective tissue and CCL 81 of monkey connective tissue) and animals (rabbit and mouse) with direct or indirect patient contact, or by the injection of specific extracts prepared from the material under test. In addition, studies involving short-term intramuscular and long-term implantation assays to estimate the reaction of living tissue to the composites studied, and investigations on long-term effects that these materials can cause on the cellular metabolism, are already in progress.
机译：用于终端用途的材料和设备（如植入物和医疗设备）必须经过评估，以确定其与生理系统接触时的生物相容性潜力。使用标准的生物测试方法可以为生物体对给定材料或设备的响应提供合理的置信度，并为选择合适的程序进行新材料或改性材料的筛选提供指导。本文通过对粉末，陶瓷体和羟基磷灰石（HA），氧化钙部分稳定的氧化锆（ZO）以及两种氧化锆的提取液进行全身和皮内注射的细胞培养，皮肤刺激和急性毒性的细胞毒性试验结果-羟基磷灰石复合材料（Z4H6和Z6H4）具有潜在的未来用作骨科和牙科植入物的潜力。它们表明这些材料具有这类用途的潜力，因为它们符合推荐用于评估ATCC细胞培养物（小鼠结缔组织的CCL1 NCTC 929和猴结缔组织的CCL 81）的生物反应性的标准实践的要求。 （兔子和老鼠）与患者直接或间接接触，或通过注射从被测材料制备的特定提取物。另外，涉及短期肌肉内和长期植入测定法以评估活组织对所研究的复合物的反应的研究以及对这些材料可能对细胞代谢造成的长期影响的研究已经在进行中。

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