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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Compliant design of artificial graft: compliance determination by new digital X-ray imaging system-based method
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Compliant design of artificial graft: compliance determination by new digital X-ray imaging system-based method

机译：人造移植物的合规设计：通过基于新型数字X射线成像系统的方法确定合规性

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摘要

The development of an artificial graft requires formulation of biomechanical design criteria. The compliance of artifical grafts, based on the intraluminal pressure-internal diameter (Pi-Di) relationship, was measured by a novel method using a digital X-ray imaging system coupled with an edge detection algorithm and a pressure transducer. The Pi-Di values were obtained from digital angiographic images under continuous inflation of a canine femoral artery anastomosed with an expanded poly(tetrafluoroethylene) (ePTFE) vascular graft as a model vessel with a pressurized contrast medium. The Di at Pi using an NIH Image software specially programmed for the entropy filter method, which enables the detection of the edge of the vessel phantoms of the images, was determined. The Pi-Di relationships showed a "J-shape" curve for the artery, a steeper line with a very low pressure-dependent distensibility for the ePTFE graft, and an intermediate curve for the anastomosis protion. The two indices for the vessel compliance, the stiffness parameter (beta value) and the diameter compliance (C_d), both of which were calculated from the Pi-Di relationships, were 10.6 and 6.8 percent/mmHg X 10~(-2) for the artery, 164 and 0.51 percent/ mmHg X 10~(-2) for the ePTFE, and 14.4 and 5.5 percent/mmHg X 10~(-2) for the anastomosis portion, respectively. This method can measure compliance at any portions of the sampling vessel in a single experiment on a real-time basis with very high accuracy, compared with conventional methods, and even in cases of intimal thickening and/or connective tissues-adhered vessels, and may serve to provide information on compliant design criteria of artificial and tissue-engineered graft.
机译：人工移植物的开发需要制定生物力学设计标准。基于腔内压力-内径（Pi-Di）关系的人造移植物的顺应性，是通过一种新颖的方法使用数字X射线成像系统结合边缘检测算法和压力传感器来测量的。 Pi-Di值是从数字血管造影图像中获得的，在连续扩张的犬股动脉中，用扩张的聚四氟乙烯（ePTFE）血管移植物将其作为具有加压造影剂的模型血管，对其进行了吻合。确定了使用专门为熵滤镜方法编程的NIH Image软件的Pi处的Di值，该方法可以检测图像的血管模型的边缘。 Pi-Di关系显示出动脉的“ J形”曲线，ePTFE移植物的较陡的线和非常低的压力依赖性扩张性，以及吻合部分的中间曲线。血管顺应性的两个指标，即刚度参数（β值）和直径顺应性（C_d），两者均通过Pi-Di关系计算得出，其对于以下指标分别为10.6％和6.8％/ mmHg X 10〜（-2）动脉，ePTFE分别为164和0.51％/ mmHg X 10〜（-2），吻合部分分别为14.4和5.5％/ mmHg X 10〜（-2）。与传统方法相比，甚至在有内膜增厚和/或结缔组织粘附的血管的情况下，该方法也可以在单个实验中以非常高的实时度实时测量采样容器中任何部位的顺应性。用于提供有关人造和组织工程移植物的合规设计标准的信息。

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