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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >The Effects of Localized Cold Work on the Heating Characteristics of Thermal Therapy Implants
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The Effects of Localized Cold Work on the Heating Characteristics of Thermal Therapy Implants

机译：局部冷作对热疗植入物加热特性的影响

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摘要

The use of cylindrical palladium- cobalt alloy rods has proven effective in the clinical ablation of prostate cancer. In order to thermally destroy tissue, the ferromagnetic implants must heat to temperatures greater than 42 deg C and produce a power output of at least 400 mW. However, localized cold work such as bending may effect the heating characteristics of these rods and have detrimental clinical effect. Three different types of test devices were manufactured to introduce cold work at one point in the implant: a sharp bend, a curvature, and an MTS three-point bend. After bending, each rod was then restraightened. Rod power output before and after bending was measured by calorimetry. Statistical comparison of power output for prebent and restraightened rods versus degrees bent was performed through the use of the SAS~R MIXED procedure to fit a mixed-model repeated-measures ANOVA with the use of multivariate models. In vitro testing showed that there was only a small change in the power output before and after rods were cold worked regardless of the type of bending. Therefore, localized cold work does not affect the clinical heating characteristics of rods.
机译：圆柱形钯钴合金棒的使用已被证明在前列腺癌的临床消融中是有效的。为了热破坏组织，铁磁植入物必须加热到高于42摄氏度的温度，并产生至少400 mW的功率输出。但是，局部冷加工（例如弯曲）可能会影响这些焊条的加热特性，并具有不利的临床效果。制造了三种不同类型的测试设备，以在植入物的某一点引入冷加工：急剧弯曲，弯曲和MTS三点弯曲。弯曲后，然后将每个杆重新矫直。通过量热法测量弯曲前后的杆功率输出。通过使用SAS〜R MIXED程序对多元弯曲模型进行拟合，以拟合混合模型重复测量方差分析，从而对弯曲和重新矫直棒的功率输出与弯曲程度进行了统计比较。体外测试表明，不管弯曲的类型如何，在棒进行冷加工之前和之后的功率输出只有很小的变化。因此，局部冷作不会影响棒材的临床加热特性。

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