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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >The long-term behavior of poly-L-lactide screws in a minipig fracture model: Preliminary report.
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The long-term behavior of poly-L-lactide screws in a minipig fracture model: Preliminary report.

机译：聚-L-丙交酯螺钉在小型猪骨折模型中的长期行为：初步报告。

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摘要

The long-term degradation tissue response to poly-L-lactide (PLLA) screw was investigated for a minipig tibia fracture. As a bone-fracture model, three PLLA screws per animal were used to fix a tibia that had been subjected to a crank-shaped osteotomy. A total of 12 nine-month-old male minipigs were used. In time period from 1 month to 3 years, clinical, radiographic, and pathological studies were conducted. On macroscopic examination, no clear granuloma or fistula formation was noted for 3 years. On microscopic examination, no osteoclasts or giant cells were detected around the screws during the 3 years postoperatively. A substantial degradation of PLLA screw was observed between 2 and 3 years. At 3 years only slight residual breakdown products were found in macrophages. On electric microscopic examination, numerous degraded polymers were seen in a small number of macrophages around the screws. In this model, fixation of tibia fractures using PLLA screws was not associated with any side effects, and was safe and useful for up to 3 years.
机译：研究了小型猪胫骨骨折对聚L-丙交酯（PLLA）螺钉的长期降解组织反应。作为骨骨折模型，每只动物使用三个PLLA螺钉固定经受曲柄形截骨术的胫骨。总共使用了12只9个月大的雄性迷你猪。在1个月至3年的时间里，进行了临床，影像学和病理学研究。肉眼检查，三年内未见明显的肉芽肿或瘘管形成。显微镜下检查，术后3年内在螺钉周围未检测到破骨细胞或巨细胞。在2至3年之间观察到了PLLA螺钉的严重降解。在3年时，在巨噬细胞中仅发现少量残留的分解产物。通过电镜检查，在螺钉周围的少量巨噬细胞中发现了许多降解的聚合物。在该模型中，使用PLLA螺钉固定胫骨骨折没有任何副作用，并且安全有效，长达3年。

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