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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Biomimetic nano-apatite coating capable of promoting bone ingrowth
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Biomimetic nano-apatite coating capable of promoting bone ingrowth

机译:能够促进骨骼向内生长的仿生纳米磷灰石涂层

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摘要

Nano-apatite coating closely mimicking bone mineral was grown directly on titanium soaked in an aqueous solution containing all major inorganic components present in the body, mainly, HCO_3, Ca~(2+), HPO_4~(2-), and Mg~(2+) ions. The removal of HCO_3 ions from the solution in the form of CO_2 resulted in the increase of solution pH. As a consequence of this reaction, the nano-apatite coating was formed on the surface of titanium with composition and structure equivalent to those of bone mineral. The biomimetic nano-apatite was demonstrated to be capable of conducting bone formation and promoting direct bone apposition. This bioactive coating also affected the behavior of human osteoblasts as indicated by their morphologies observed in cell culture study.
机译:纳米磷灰石涂层非常类似于骨骼矿物质,直接在浸泡在含有人体中所有主要无机成分的水溶液中的钛上直接生长,其中主要成分是HCO_3,Ca〜(2 +),HPO_4〜(2-)和Mg〜( 2+)离子。从溶液中以CO_2的形式除去HCO_3离子导致溶液pH值增加。作为该反应的结果,在钛表面上形成了具有与骨矿物质相同的组成和结构的纳米磷灰石涂层。仿生纳米磷灰石被证明能够进行骨形成并促进直接骨并置。这种生物活性涂层还影响到人类成骨细胞的行为,正如在细胞培养研究中观察到的形态所表明的那样。

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