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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Effects of lithium fluoride and maleic acid on the bioactivity of calcium aluminate cement: Formation of hydroxyapatite in simulated body fluid
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Effects of lithium fluoride and maleic acid on the bioactivity of calcium aluminate cement: Formation of hydroxyapatite in simulated body fluid

机译：氟化锂和马来酸对铝酸钙水泥生物活性的影响：模拟体液中羟基磷灰石的形成

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摘要

To improve the bioactivity of calcium aluminate cement (CAC), which has the potential of restoring defective bone and the joints between artificial prostheses and natural bone, lithium fluoride and maleic acid were added to CAC. Then the bioactivity of the CAC, together with the lithium fluoride and maleic acid, was estimated by examining the hydroxyapatite (HAp) formation on its surface in simulated body fluid (SBF). When 0.5 g of lithium fluoride and 8.75 g of maleic acid were added to 100 g of CAC, LiAl_2(OH)_7 centre dot 2H_2O was formed on the surface of CAC after 1 day of soaking, and HAp was formed after 2 days. The depth of the LiAl_2(OH)_7 centre dot 2H_2O and HAp-mixed layers after 60 days of immersion was approximately 20 mum. However, after CAC, which contains only 8.75 g of maleic acid per 100 g of CaO centre dot Al_2O_3, had been soaking for just 30 days, 3CaO centre dot Al_2O_3 centre dot 6H_2O and HAp were detected. These results indicate that lithium fluoride accelerates HAp formation on the surface of CAC in SBF while maleic acid has little influence on HAp formation. The promotion of HAp formation on the surface of CAC in SBP can be explained in terms of the he)p of an intermediate layer, LiAl_2(OH)_7 centre dot 2H_2O, which contains hydroxyl groups that act as the nuclei of HAp formation and a tremendous dissolution of calcium ions from CAC into the SBF solution within a short induction time.
机译：为了提高铝酸钙水泥（CAC）的生物活性，铝酸钙水泥具有修复缺损的骨骼和人造假体与天然骨骼之间的关节的潜力，在CAC中添加了氟化锂和马来酸。然后，通过检查模拟体液（SBF）中表面上的羟基磷灰石（HAp）形成，来评估CAC以及氟化锂和马来酸的生物活性。当将0.5g的氟化锂和8.75g的马来酸添加到100g的CAC中时，在浸泡1天后在CAC的表面上形成LiAl_2（OH）_7中心点2H_2O，并且在2天后形成HAp。浸泡60天后，LiAl_2（OH）_7中心点2H_2O和HAp混合层的深度约为20微米。但是，在每100克CaO中心点Al_2O_3中仅含有8.75克马来酸的CAC浸泡仅30天后，检测到3CaO中心点Al_2O_3中心点6H_2O和HAp。这些结果表明，氟化锂促进了SBF中CAC表面的HAp形成，而马来酸对HAp形成的影响很小。可以通过中间层LiAl_2（OH）_7中心点2H_2O的hep来解释SBP中CAC表面HAp形成的促进作用，该中间层包含充当HAp形成核的羟基和在短诱导时间内，钙离子从CAC大量溶解到SBF溶液中。

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