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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Antibacterial properties of nitric oxide-releasing sol-gels
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Antibacterial properties of nitric oxide-releasing sol-gels

机译:一氧化氮释放溶胶凝胶的抗菌性能

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摘要

The antibacterial characteristics of nitric oxide (NO)-releasing sol-gel coatings are described. The NO release from these surfaces is steady over short periods (approx= 1 h) and measurable over several days. The ability of NO to prevent bacterial adhesion is evaluated by exposing controls and NO-releasing sol-gels to approx= 10~8 colony-forming units (cfu)/mL saline suspensions of Pseudomonas aeruginosa. Pseudomonas aeruginosa adhesion to sol-gel controls varies depending on the sol-gel formulation. Sol-gel surfaces capable of NO release decrease bacterial adhesion by 30 percent to 95 percent relative to controls. The contact angle measurements of control and NO-releasing surfaces are similar, supporting NO's action as an antibacterial agent against bacterial adhesion.
机译:描述了释放一氧化氮(NO)的溶胶-凝胶涂层的抗菌特性。从这些表面释放的NO在短时间内(约1小时)稳定,并在几天内可测量。通过将对照和释放NO的溶胶-凝胶暴露于约10〜8个铜绿假单胞菌的菌落形成单位(cfu)/ mL盐水悬浮液中来评估NO防止细菌粘附的能力。铜绿假单胞菌对溶胶-凝胶对照的粘附性随溶胶-凝胶制剂而变化。相对于对照,能够释放NO的溶胶-凝胶表面可将细菌附着力降低30%至95%。控制表面和释放NO的表面的接触角测量结果相似,支持NO作为抗细菌附着力的抗菌剂的作用。

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