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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Osteogenecity of octacalcium phosphate coatings applied on porous metal implants
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Osteogenecity of octacalcium phosphate coatings applied on porous metal implants

机译：应用于多孔金属植入物的磷酸八钙涂层的成骨性

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摘要

The biomimetic route allows the homogeneous deposition of calcium phosphate (Ca-P) coatings on porous implants by immersion in simulated physiologic solution. In addition, various Ca-P phases, such as octacalcium phosphate (OCP) or bone-like carbonated apatite (BCA), which are stable only at low temperatures, can be deposited. In this pilot study, experiments were designed with a twofold-purpose: (1) to investigate the osteoinduction of OCP-coated and noncoated porous tantalum cylinders and of dense titanium alloy cylinders (5 mm in diameter and 10 mm in length) in the back muscle of goats at 12 and 24 weeks (n = 4); and (2) to compare the osteogenic potentials of BCA-coated, OCP-coated, and bare porous tantalum cylinders in a gap of 1 mm created in the femoral condyle of a goat at 12 weeks (n = 2). In the goat muscle, after 12 weeks the OCP-coated porous cylinder had induced ectopic bone as well as bone within the cavity of the OCP-coated dense titanium cylinder. In the femoral condyle, bone did not fill the gap in any of the porous implants. In contrast with the two other groups, OCP-coated porous cylinders exhibited bone formation in the center of the implant. The nature of the Ca-P coating, via its microsiructure, its dissolution rate, and its specific interactions with body fluids, may influence the osteogenecity of the Ca-P biomaterial.
机译：仿生途径通过浸入模拟生理溶液中，使磷酸钙（Ca-P）涂层均匀地沉积在多孔植入物上。此外，可以沉积仅在低温下稳定的各种Ca-P相，例如磷酸八钙（OCP）或骨状碳酸磷灰石（BCA）。在该初步研究中，设计了双重目的的实验：（1）研究背面有OCP涂层和未涂层​​的多孔钽圆柱体以及致密钛合金圆柱体（直径5 mm，长度10 mm）的骨诱导12和24周时山羊的肌肉（n = 4）; （2）比较12周时在山羊股骨）中形成的1 mm间隙中BCA涂层，OCP涂层和裸露的多孔钽圆柱体的成骨潜力（n = 2）。在山羊肌肉中，经过12周的OCP涂层的多孔圆柱体已经诱导了异位骨以及OCP涂层的致密钛圆柱体的空腔内的骨骼。在股骨dy中，骨没有填充任何多孔植入物的间隙。与另外两组相比，OCP涂层的多孔圆柱体在植入物的中心呈现出骨形成。 Ca-P涂层的性质，通过其微结构，其溶解速率以及与体液的特定相互作用，可能会影响Ca-P生物材料的成骨性。

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