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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Polymeric matrices based on graft copolymers of PCL onto acrylic backbones for releasing antitumoral drugs
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Polymeric matrices based on graft copolymers of PCL onto acrylic backbones for releasing antitumoral drugs

机译：基于PCL在丙烯酸骨架上的接枝共聚物的聚合物基体，用于释放抗肿瘤药物

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摘要

Craft copolymers of poly(epsilon-caprolactone) (PCL) on poly(dimethylacrylamide) (PDMAm), poly(methylmethacrylate) (PMMA), or on copolymers of poly(DMAm-co-MMA) have been synthesized and characterized by 1H NMR spectroscopy, differential scanning calorimetry (DSC), and size exclusion chromatography (SEC). These partially biodegradable copolymer matrices have been proposed as drug delivery systems for the release of low-molecular-weight glycosides. Octyl-N-acetyl-6-O-[2,2-bis(hydroxymethyl)-3-hydroxypropyl]-alpha-D-glucosamide, a synthetic carbohydrate able to inhibit the proliferation of human malignant glioma cells in culture and transplanted glioma in rats was selected as drug model. The in vitro aqueous behavior of four drug-loaded and unloaded graft copolymers of different MMA: DMAm and PCL ratios has been analyzed performing swelling, degradation, and drug release experiments. An intimate dependence of the aqueous behavior with the composition has been found. The higher was the DMAm content, the higher was the hydrophilicity of the synthesized systems as well as the swelling, degradation, and drug release rate. In vivo experiments in pigs demonstrated the very good tolerance of drug-loaded implanted polymeric discs, and that >95 percent of the charged drug is released after 2 months' implantation.
机译：合成了聚ε-己内酯（PCL）在聚（二甲基丙烯酰胺）（PDMAm），聚（甲基丙烯酸甲酯）（PMMA）或聚（DMAm-co-MMA）共聚物上的工艺共聚物，并通过1H NMR光谱进行了表征，差示扫描量热法（DSC）和尺寸排阻色谱法（SEC）。已经提出这些可部分生物降解的共聚物基质作为释放低分子量糖苷的药物递送系统。辛基-N-乙酰基-6-O- [2,2-双（羟甲基）-3-羟丙基]-α-D-葡糖酰胺，一种能够抑制人恶性神经胶质瘤细胞在培养和移植后的神经胶质瘤中增殖的合成碳水化合物。选择大鼠作为药物模型。进行了溶胀，降解和药物释放实验，分析了四种不同的MMA：DMAm和PCL比值的载药和未载药接枝共聚物的体外水性行为。已经发现水性行为与组合物密切相关。 DMAm含量越高，合成系统的亲水性以及溶胀，降解和药物释放速率就越高。猪体内实验表明，载有药物的聚合物椎间盘具有很好的耐受性，并且植入2个月后，有95％的带电药物被释放。

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