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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Biocompatibility of adenoviral vectors in poly(vinyl chloride) tubing catheters with presence or absence of plasticizer di-2-ethylhexyl phthalate
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Biocompatibility of adenoviral vectors in poly(vinyl chloride) tubing catheters with presence or absence of plasticizer di-2-ethylhexyl phthalate

机译：含有或不含有增塑剂邻苯二甲酸二-2-乙基己酯的聚氯乙烯导管中腺病毒载体的生物相容性

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摘要

Adenoviral (Ad) vectors feature attractive characteristics for gene therapy of a wide variety of diseases. In many cases, the Ad vector must be administered using catheters and other plastic medical devices. Although poly(vinyl chloride) is one of the most frequently used catheter materials, it is relatively rigid and requires the addition of a plasticizer such as di-2-ethylhexyl phthalate (DEHP) to increase its flexibility. In this study, we demonstrated that exposure to a DEHP-containing catheter decreased the infectivity of Ad vectors but not the total particle number of the vector. Loss of Ad vector infectivity was directly related to the time of exposure to the DEHP-containing catheter, but it was not due to simple leaching of the chemical from the plastic. The loss of Ad vector infectivity could be prevented by preflushing the tube with albumin. Careful consideration of the compatibility between gene therapy vectors and medical delivery devices will be critical to the success of human gene therapy applications.
机译：腺病毒（Ad）载体具有用于多种疾病的基因治疗的诱人特性。在许多情况下，必须使用导管和其他塑料医疗设备来投放Ad载体。尽管聚氯乙烯是最常用的导管材料之一，但它相对较硬，需要添加增塑剂，例如邻苯二甲酸二-2-乙基己酯（DEHP），以增加其柔韧性。在这项研究中，我们证明了暴露于含有DEHP的导管会降低Ad载体的感染性，但不会降低载体的总颗粒数。 Ad载体传染性的丧失与暴露于含DEHP的导管的时间直接相关，但这不是由于化学物质从塑料中浸出的简单原因。通过用白蛋白预冲洗试管，可以防止Ad载体传染性的丧失。仔细考虑基因治疗载体和医疗输送设备之间的兼容性对于人类基因治疗应用的成功至关重要。

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