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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Injectable and rapid-setting calcium phosphate bone cement with dicalcium phosphate dihydrate.
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Injectable and rapid-setting calcium phosphate bone cement with dicalcium phosphate dihydrate.

机译：可注射的速凝磷酸钙骨水泥与磷酸二钙二水合物。

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Calcium phosphate cement (CPC) sets in situ with intimate adaptation to the contours of defect surfaces, and forms an implant having a structure and composition similar to hydroxyapatite, the putative mineral in teeth and bones. The objective of the present study was to develop an injectable CPC using dicalcium phosphate dihydrate (DCPD) with a high solubility for rapid setting. Two agents were incorporated to impart injectability and fast-hardening to the cement: a hardening accelerator (sodium phosphate) and a gelling agent (hydroxypropyl methylcellulose, HPMC). The cement with DCPD was designated as CPC(D), and the conventional cement was referred to as CPC(A). Using water without sodium phosphate, CPC(A) had a setting time of 82 +/- 6 min. In contrast, CPC(D) exhibited rapid setting with a time of 17 +/- 1 min. At 0.2 mol/L sodium phosphate, setting time for CPC(D) was 15 +/- 1 min, significantly faster than 40 +/- 2 min for CPC(A) (Tukey's at 0.95). Sodium phosphate decreased the paste injectability (measured as the paste mass extruded from the syringe divided by the original paste mass inside the syringe). However, the addition of HPMC dramatically increased the paste injectability. For CPC(D), the injectability was increased from 65% +/- 12% without HPMC to 98% +/- 1% with 1% HPMC. Injectability of CPC(A) was also doubled to 99% +/- 1%. The injectable and rapid-setting CPC(D) possessed flexural strength and elastic modulus values overlapping the reported values for sintered porous hydroxyapatite implants and cancellous bone. In summary, the rapid setting and relatively high strength and elastic modulus of CPC(D) should help the graft to quickly attain strength and geometrical integrity within a short period of time postoperatively. Furthermore, the injectability of CPC(D) may have potential for procedures involving defects with limited accessibility or narrow cavities, when there is a need for precise placement of the paste, and when using minimally invasive surgical techniques.
机译：磷酸钙水泥（CPC）在原位凝固，与缺陷表面的轮廓紧密匹配，并形成一种植入物，其结构和成分类似于羟基磷灰石，后者是牙齿和骨骼中的假定矿物。本研究的目的是开发使用高溶解度的磷酸二钙二水合物（DCPD）进行快速凝固的可注射CPC。掺入两种试剂以赋予水泥注射性和快速硬化性：硬化促进剂（磷酸钠）和胶凝剂（羟丙基甲基纤维素，HPMC）。具有DCPD的水泥被称为CPC（D），而常规水泥被称为CPC（A）。使用不含磷酸钠的水，CPC（A）的凝固时间为82 +/- 6分钟。相反，CPC（D）表现出快速凝固，时间为17 +/- 1分钟。在0.2 mol / L磷酸钠下，CPC（D）的凝固时间为15 +/- 1分钟，大大快于CPC（A）的40 +/- 2分钟（Tukey的值为0.95）。磷酸钠降低了糊剂的可注射性（以从注射器中挤出的糊剂质量除以注射器内部的原始糊剂质量来衡量）。但是，HPMC的加入大大提高了糊料的可注射性。对于CPC（D），可注射性从不使用HPMC的65％+/- 12％增加到使用1％HPMC的98％+/- 1％。 CPC（A）的可注射性也翻了一番，达到99％+/- 1％。可注射且快速凝固的CPC（D）的抗弯强度和弹性模量值与烧结的多孔羟基磷灰石植入物和松质骨的报道值重叠。综上所述，CPC（D）的快速凝固以及相对较高的强度和弹性模量应有助于术后短时间内迅速获得强度和几何完整性。此外，CPC（D）的可注射性可能会涉及涉及具有有限可及性或狭窄空腔的缺陷的程序，当需要精确放置糊剂时以及使用微创外科手术技术时。

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