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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Drug entrapment in silica microspheres through a single step sol-gel process and in vitro release behavior.
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Drug entrapment in silica microspheres through a single step sol-gel process and in vitro release behavior.

机译：通过一步法溶胶-凝胶法和体外释放行为将药物截留在二氧化硅微球中。

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摘要

A single step sol-gel process was used to precipitate silica microspheres containing ibuprofen or naproxen for controlled drug delivery applications. The drug release behavior from these systems was analyzed in vitro. Pure ibuprofen and naproxen exhibited linear release with time, while sol-gel silica entrapped drugs were released with a logarithmic time dependence starting with an initial burst effect followed by a gradual decrease. Microscopic analysis combined with gravimety and infrared spectroscopy indicated that some of the drug is entrapped as large crystals attached to silica microspheres while the rest is encapsulated inside the microspheres. Drug-loaded silica microspheres with no open porosity and with a narrow particle size distribution were obtained. Both erosion of the microspheres and diffusion through them contributed to drug release. Sol-gel precipitation of silica microspheres is a promising method for drug entrapment and controlled release.
机译：一步溶胶-凝胶法用于沉淀含有布洛芬或萘普生的二氧化硅微球，用于可控药物递送应用。从这些系统中的药物释放行为进行了体外分析。纯布洛芬和萘普生随时间呈线性释放，而溶胶-凝胶硅胶包裹的药物以对数时间依赖性释放，从初始爆发效应开始，然后逐渐降低。结合重力和红外光谱的显微镜分析表明，某些药物以附着在二氧化硅微球上的大晶体的形式被截留，而其余药物则封装在微球内部。获得了无开孔且窄粒度分布的载药二氧化硅微球。微球的侵蚀和通过微球的扩散均导致药物释放。二氧化硅微球的溶胶-凝胶沉淀法是一种用于药物截留和控释的有前途的方法。

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