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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Graft copolymers of methyl methacrylate and poly((R)-3-hydroxybutyrate) macromonomers as candidates for inclusion in acrylic bone cement formulations: Compression testing.
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Graft copolymers of methyl methacrylate and poly((R)-3-hydroxybutyrate) macromonomers as candidates for inclusion in acrylic bone cement formulations: Compression testing.

机译：甲基丙烯酸甲酯和聚（R）-3-羟基丁酸酯大单体的丙烯酸共聚物接枝共聚物，包括在丙烯酸骨水泥配方中：压缩测试。

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摘要

Graft copolymers of methyl methacrylate and biodegradable, biocompatible bacterial poly([R]-3-hydroxybutyrate) (PHB) blocks were synthesized and evaluated as possible constituents in acrylic bone cements for use in orthopaedic applications. The copolymers were produced by conventional free radical copolymerization and incorporated in one commercially available acrylic bone cement brand, Antibiotic Simplex (AKZ). Cements with formulations containing 6.7 and 13.5 wt % of PMMA-graft-PHB were prepared. The morphology of the graft copolymer particles was suggested to influence the ability of the modified cement to be processed. Formulations containing more than about 20 wt % of the graft copolymer resulted in cement doughs that, both after first preparation and several hours later, were either sandy or soft spongy in texture and, thus, would be unacceptable for use in orthopaedic applications. The morphologies of the powders and the volumetric porosity (p) and ultimate compressive strength (UCS) of the cured cements were determined. Micro computed tomography showed that the cements presented average porosities of 13.5-16.9%. It was found that, while the powder particle shape and size for the experimental cements were markedly different from those of AKZ, there was no significant difference in either p or UCS for these cements. The latter was determined to be about 85 MPa for the modified cements and 84 MPa for Antibiotic Simplex. Furthermore, the UCS of all the cements exceeded the minimum level for acrylic bone cements, as stipulated by ASTM F-451.
机译：合成了甲基丙烯酸甲酯和可生物降解的生物相容性细菌聚（[R] -3-羟基丁酸酯）（PHB）嵌段的接枝共聚物，并将其评估为用于骨科应用的丙烯酸类骨水泥中的可能成分。该共聚物通过常规的自由基共聚反应制得，并掺入一种可商购的丙烯酸骨水泥品牌，Antibiotic Simplex（AKZ）。制备具有包含6.7和13.5重量％的PMMA-接枝-PHB的制剂的水泥。认为接枝共聚物颗粒的形态影响改性水泥的加工能力。包含大于约20wt％的接枝共聚物的制剂产生的水泥生面团，在第一次制备后和几个小时后，其质地均为沙状或软海绵状，因此在整形外科应用中将是不可接受的。测定了粉末的形态，固化水泥的体积孔隙率（p）和极限抗压强度（UCS）。显微计算机断层扫描显示，水泥的平均孔隙率为13.5-16.9％。结果发现，虽然实验用水泥的粉末颗粒形状和尺寸与AKZ的明显不同，但这些水泥的p或UCS均无显着差异。对于改性水泥，后者被确定为约85 MPa，而对于抗生素单纯形，后者为84 MPa。此外，所有水泥的UCS都超过了ASTM F-451规定的丙烯酸骨水泥的最低含量。

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