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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Evaluation of ion release, cytotoxicity, and platelet adhesion of electrochemical anodized 316 L stainless steel cardiovascular stents.
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Evaluation of ion release, cytotoxicity, and platelet adhesion of electrochemical anodized 316 L stainless steel cardiovascular stents.

机译：评估电化学阳极氧化316 L不锈钢心血管支架的离子释放，细胞毒性和血小板粘附性。

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316L Stainless steel is one of the most used metallic material in orthopedical prosthesis, osteosinthesis plates, and cardiovascular stents. One of the main problems this material presents is the nickel and chromium release, specially the Ni ion release that provokes allergy in a high number of patients. Recently, experimental applications in vitro and in vivo seem to indicate that the thickness of the nature oxide of the stainless steel results in very strong reinforcement of the biological response and reduce the ion release due to the thicker surface oxide. It is possible to grow the natural chromium oxide layer by electrolytic method such anodization. In this study, two main anodization methods to grow chromium oxide on the 316L stainless steel have been evaluated. Nickel and Chromium ions release in human blood at 37 degrees C were detected at times of 1, 6, 11, and 15 days by means of atomic absorption in a graphite furnace (GAAF). Moreover, cytocompatibility tests were carried out. Perfusion experiments were performed to evaluate morphometrically platelet interaction with the material and to explore the potential thrombogenicity. The results showed a good cytocompatibility between the material and the osteoblast-like cells. However, these anodization methods released between 2 and 10 times more nickel and chromium than the original stainless steel, depending on the method used. Besides, anodized samples shown an increase of the percentage of surface covered by platelets. Consequently, the anodization methods studied do not improve the long-term behavior of the stainless steel for its application as cardiovascular stents.
机译：316L不锈钢是整形外科假体，接骨板和心血管支架中最常用的金属材料之一。这种材料存在的主要问题之一是镍和铬的释放，特别是镍离子的释放，在许多患者中引起过敏。近来，体外和体内的实验应用似乎表明，不锈钢的自然氧化物的厚度导致非常强的生物响应增强，并且由于较厚的表面氧化物而减少了离子释放。可以通过诸如阳极氧化的电解方法来生长天然氧化铬层。在这项研究中，评估了在316L不锈钢上生长氧化铬的两种主要阳极氧化方法。通过石墨炉（GAAF）中的原子吸收，分别在1天，6天，11天和15天的时间检测到了37摄氏度时在人体血液中释放的镍和铬离子。此外，进行了细胞相容性测试。进行灌注实验以评估形态上血小板与物质的相互作用，并探讨潜在的血栓形成性。结果显示该材料与成骨样细胞之间具有良好的细胞相容性。但是，根据所使用的方法，这些阳极氧化方法释放的镍和铬比原始不锈钢多2至10倍。此外，阳极氧化样品显示出被血小板覆盖的表面的百分比增加。因此，所研究的阳极氧化方法不能改善不锈钢作为心血管支架的长期性能。

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