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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Wear particle analysis of highly crosslinked polyethylene isolated from a failed total hip arthroplasty.
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Wear particle analysis of highly crosslinked polyethylene isolated from a failed total hip arthroplasty.

机译：从全髋关节置换术失败中分离出的高度交联聚乙烯的磨损颗粒分析。

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摘要

Polyethylene wear particles are one of the most important factors affecting the results of total hip arthroplasty (THA). To reduce wear generation and to achieve better long-term results of THA, highly crosslinked polyethylene (HXPE) has recently been introduced and come into wide use. Thus far, however, there have been no reports on in vivo analysis of HXPE wear particles. We isolated HXPE wear particles from periprosthetic tissue of a failed THA and analyzed using scanning electron microscope. The number of particles was 5.33 x 10(7) g(-1). Particle size (equivalent circle diameter) was 0.66 +/- 0.40 microm (mean +/- standard error). Aspect ratio and roundness were 1.37 +/- 0.26 and 1.44 +/- 0.67, respectively. All the particles were round shaped, and "fibrils" or "shreds" were not detected. Thus far, this was the first report on in vivo wear particle analysis of HXPE. HXPE generated less, smaller, and rounder particles, compared with the corresponding reported values for particles generated from conventional polyethylene. These characteristics might affect macrophage response, osteolysis, and long-term results of THA with HXPE.
机译：聚乙烯磨损颗粒是影响全髋关节置换术（THA）结果的最重要因素之一。为了减少磨损的产生并获得更好的THA长期效果，最近已经引入并广泛使用了高度交联的聚乙烯（HXPE）。然而，迄今为止，还没有关于体内分析HXPE磨损颗粒的报道。我们从失败的THA的假体周围组织中分离出HXPE磨损颗粒，并使用扫描电子显微镜进行了分析。颗粒数为5.33×10（7）g（-1）。粒度（当量圆直径）为0.66 +/- 0.40微米（平均+/-标准误差）。长宽比和圆度分别为1.37 +/- 0.26和1.44 +/- 0.67。所有颗粒均为圆形，未检测到“原纤维”或“碎片”。迄今为止，这是有关HXPE体内磨损颗粒分析的第一份报告。与从常规聚乙烯产生的颗粒的相应报道值相比，HXPE产生的颗粒更少，更小且更圆。这些特征可能会影响巨噬细胞反应，溶骨作用以及HXPE与THA的长期结果。

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