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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Impactability and time-dependent mechanical properties of porous titanium particles for application in impaction grafting.
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Impactability and time-dependent mechanical properties of porous titanium particles for application in impaction grafting.

机译：用于冲击接枝的多孔钛粒子的冲击性和随时间变化的机械性能。

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AIMS: Impaction grafting with bone particles is a successful technique to restore bone stock loss during hip revision surgery. Allograft shortage is expected within the near future. This study investigates the feasibility of porous titanium particles (TiP) to replace bone particles (BoP) and to compare mechanical properties of TiP and a commercially available porous ceramic bone graft extender (CeP). Impactability and time-dependent mechanical properties (stability and stiffness during physiologic loading (0.1-2.5 MPa)) were assessed by standardized impaction and a confined compression test. Loaded samples were used for particle release analysis. FINDINGS: TiP were more impactable than BoP and created a stable, highly entangled macroporous construct. CeP were crushed during impaction, resulting in non-cohesive specimens of small ceramic particles. TiP showed very little deformation at the end of physiological loading. Impacted TiP were stiffer than BoP but more elastic than CeP. TiP generated a low volume of microparticles (0.2% of original TiP weight) with a bimodal size distribution (diameter range, 7-2000 microm). CONCLUSION: TiP are impactable and create a stable, elastic and highly entangled, macroporous layer. Further in-vitro testing and biological studies are warranted to verify whether the promising results are maintained with THA reconstructions.
机译：目的：植骨术是一种成功的技术，可以在髋关节翻修手术中恢复骨质流失。预计同种异体移植物短缺。这项研究调查了多孔钛颗粒（TiP）替代骨颗粒（BoP）的可行性，并比较了TiP和市售多孔陶瓷骨移植扩展剂（CeP）的机械性能。冲击力和随时间变化的机械性能（生理负荷下的稳定性和刚度（0.1-2.5 MPa））通过标准冲击力和密闭压缩试验进行评估。加载的样品用于颗粒释放分析。结果：TiP比BoP更易受影响，并创建了稳定的，高度纠缠的大孔结构。 CeP在撞击过程中被压碎，产生了小陶瓷颗粒的非粘性标本。 TiP在生理负荷结束时几乎没有变形。受影响的TiP比BoP坚硬，但比CeP更具弹性。 TiP生成的微粒体积很小（占原始TiP重量的0.2％），具有双峰尺寸分布（直径范围为7-2000微米）。结论：TiP具有抗冲击性，可形成稳定，弹性和高度纠缠的大孔层。必须进行进一步的体外测试和生物学研究，以验证通过THA重建能否保持有希望的结果。

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