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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >A biodegradable electrical bioconductor made of polypyrrole nanoparticles/poly(D,L-lactide) composite: A preliminary in vitro biostability study
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A biodegradable electrical bioconductor made of polypyrrole nanoparticles/poly(D,L-lactide) composite: A preliminary in vitro biostability study

机译：由聚吡咯纳米颗粒/聚（D，L-丙交酯）复合材料制成的可生物降解的电生物导体：初步的体外生物稳定性研究

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The electrical stability of a novel polypyrrole (PPy)/poly(D,L-lactide) (PDLLA) composite was studied in vitro and compared with that of PPy-coated polyester fabrics. Specimens were incubated in Ringer's solution at 37 deg C for up to 8 weeks with or without the circulation of DC current under a constant 100 mV voltage. In situ current variation with incubation time was recorded. The AC volume electrical conductivity of the specimens before and after incubation in phosphate-buffered saline was recorded using a frequency analyzer. Water absorption and weight loss were monitored metrologically. Changes in the oxidation state of incubated PPy were analyzed with X-ray photoelectron spectroscopy. The morphological changes were observed with scanning electron microscopy, and the glass transition temperature of the PDLLA was investigated using differential scanning calorimetry. The PPy/PDLLA composite in Ringer's solution sustained a relatively stable conductivity up to 8 weeks after an initial period of "conditioning." The PPy-coated fabrics experienced a rapid loss of conductivity when subjected to electrical circulation and regained part of it when disconnected. The volume conductivity of the nonincubated PPy/PDLLA membrane behaved as a typical conductor in the low-frequency range. The mechanisms involved in the various electrical behaviours of the PPy/PDLLA composite and PPy-coated fabrics are discussed. In conclusion, the PPy/PDLLA composite was able to deliver a biologically significant electrical current in a simulated biological solution for up to 8 weeks and therefore may be considered as a first-generation synthetic biodegradable bioconductor.
机译：在体外研究了新型聚吡咯（PPy）/聚（D，L-丙交酯）（PDLLA）复合材料的电稳定性，并将其与涂有PPy的聚酯织物进行了比较。样品在林格氏液中于37摄氏度下孵育8周，无论有无直流电流在恒定100 mV电压下循环。记录原位电流随孵育时间的变化。使用频率分析仪记录在磷酸盐缓冲液中孵育之前和之后的标本的交流体积电导率。计量监测吸水率和体重减轻。用X射线光电子能谱分析了孵育的PPy的氧化态变化。用扫描电子显微镜观察形态变化，并使用差示扫描量热法研究PDLLA的玻璃化转变温度。林格氏溶液中的PPy / PDLLA复合材料在初始“调理”阶段后的8周内仍保持相对稳定的电导率。进行电循环后，涂有PPy的织物会迅速失去导电性，而在断开连接时会恢复部分导电性。未孵育的PPy / PDLLA膜的体积电导率在低频范围内表现为典型的导体。讨论了与PPy / PDLLA复合材料和PPy涂层织物的各种电性能有关的机理。总之，PPy / PDLLA复合材料能够在长达8周的模拟生物溶液中传递生物学上重要的电流，因此可以被视为第一代合成可生物降解的生物导体。

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