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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Polymers with nano-dimensional surface features enhance bladder smooth muscle cell adhesion
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Polymers with nano-dimensional surface features enhance bladder smooth muscle cell adhesion

机译：具有纳米表面特征的聚合物可增强膀胱平滑肌细胞的附着力

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摘要

Previous studies investigating the design of synthetic bladder wall substitutes have involved polymers with micro dimensional structures. Since the body is made up of nano-structured components (e.g., extracellular matrix proteins), the focus of the present in vitro study was to design nano-structured polymers for use as synthetic bladder constructs that mimic the topography of natural bladder tissue. In order to complete this task, novel nano-structured biodegradable polymeric films of poly-lactic-co-glycolic-acid (PLGA), poly-ether-urethane (PU), and poly-caprolactone (PCL) were fabricated and separately treated with various concentrations of NaOH (for PLGA and PCL) and HNO_3 (for PU) for select time periods. These treatments reduced the polymer surface feature dimensions from conventional micron dimensions to biologically inspired nanometer dimensions. Select cytocompatibility properties of these biomaterials were tested in vitro. Results provide the first evidence that adhesion of bladder smooth muscle cells is enhanced as polymer surface feature dimensions are reduced into the nanometer range. In addition, surface analysis results reveal that the polymer nanometer surface roughness is the primary design parameter that increases bladder smooth muscle cell adhesion. For this reason, the "next generation" of tissue-engineered bladder constructs with increased efficacy should contain surfaces with nanometer (as opposed to micron) surface features.
机译：先前研究合成膀胱壁替代物设计的研究涉及具有微观结构的聚合物。由于身体由纳米结构的成分（例如细胞外基质蛋白）组成，因此本体外研究的重点是设计纳米结构的聚合物，以用作模仿天然膀胱组织的地形的合成膀胱构造。为了完成此任务，制造了新型的纳米结构的可生物降解的聚乳酸-乙醇酸共聚物（PLGA），聚醚-氨基甲酸酯（PU）和聚己内酯（PCL）聚合物薄膜，并分别进行了处理。在选定的时间段内使用各种浓度的NaOH（对于PLGA和PCL）和HNO_3（对于PU）。这些处理将聚合物表面特征尺寸从常规的微米尺寸减小到生物学启发的纳米尺寸。在体外测试了这些生物材料的选定细胞相容性。结果提供了第一个证据，表明随着聚合物表面特征尺寸减小到纳米范围，膀胱平滑肌细胞的粘附力得到增强。此外，表面分析结果表明，聚合物纳米表面粗糙度是增加膀胱平滑肌细胞粘附力的主要设计参数。因此，功效增强的组织工程膀胱构造的“下一代”应包含具有纳米（而不是微米）表面特征的表面。

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