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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Effect of enamel matrix proteins on the periodontal connective tissue-material interface after wound healing
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Effect of enamel matrix proteins on the periodontal connective tissue-material interface after wound healing

机译：釉质基质蛋白对伤口愈合后牙周结缔组织-材料界面的影响

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The periodontal ligament has the potential to regenerate a complete periodontal connective tissue attachment, starting with the deposition of cementum, on pathologically exposed root surfaces as well as several materials including titanium oxide. However, most commonly used dental materials result in a fibrous encapsulation or a chronic inflammatory response after periodontal wound healing rather than the formation of a periodontal connective tissue attachment. Recently, an extract of porcine enamel matrix (Emdogain~R, EMD) has been reported inductive of cementum formation in both in vivo and in vitro studies. The aim of this study was to determine the effect of EMD, when applied to materials previously reported not supportive of periodontal connective tissue formation, on the periodontal connective tissue-material interface obtained with these materials in vivo. Bilateral osteotomies were performed on the mandible of a Yucatan minipig exposing the buccal root surface of four premolars. A series of four preparations were placed in each root surface that were subsequently filled with calcium hydroxide, gutta percha, mineral trioxide aggregate (MTA), or left unfilled. One side, in addition, received an application of EMD prior to surgical closure. A bioabsorbable surgical barrier membrane was placed over the osteotomy sites to exclude gingival connective tissue from the wound-healing environment. The mucoperiosteal flaps were then readapted and sutured in position. The animal was euthanized 10 weeks after the procedure, block sections obtained and prepared for light microscopy. Results demonstrated complete regeneration of alveolar bone and periodontal ligament in all four teeth from the EMD-treated side. Fibers from the periodontal ligament were observed to insert into a mineralized matrix consistent with cementum on all four root preparations. In contrast, massive root resorption without regeneration of alveolar bone was found on all teeth from the side not treated with EMD. The results of this pilot study suggest that the application of EMD to material surfaces that normally do not support periodontal connective tissue attachment formation can alter the type of periodontal connective tissue interface obtained with these materials.
机译：牙周膜有可能在病理暴露的牙根表面以及包括氧化钛在内的多种材料上再生出完整的牙周结缔组织附着，从牙骨质的沉积开始。然而，最常用的牙科材料在牙周伤口愈合后导致纤维包封或慢性炎症反应，而不是牙周结缔组织附着的形成。最近，在体内和体外研究中都报道了猪牙釉质基质（Emdogain_R，EMD）的提取物诱导牙骨质形成。这项研究的目的是确定EMD应用于以前报道不支持牙周结缔组织形成的材料时，对这些材料在体内获得的牙周结缔组织-材料界面的影响。在尤卡坦小型猪的下颌骨上进行双侧截骨术，暴露四个前磨牙的颊根表面。将一系列四种制剂放置在每个根部表面，然后用氢氧化钙，牙胶，三氧化二矿骨料（MTA）填充或不填充。另外，一侧在手术闭合之前接受了EMD的应用。将可生物吸收的外科手术屏障膜放置在截骨部位上，以从伤口愈合环境中排除牙龈结缔组织。然后将粘膜骨膜瓣重新贴紧并缝合就位。手术10周后对动物实施安乐死，获得块状切片并准备用于光学显微镜检查。结果表明，从EMD处理的一侧，所有四个牙齿中的牙槽骨和牙周膜完全再生。观察到来自牙周膜的纤维插入所有四种牙根制剂中与牙骨质一致的矿化基质中。相反，在未用EMD处理的一侧的所有牙齿上均发现大量牙根吸收而牙槽骨没有再生。这项初步研究的结果表明，将EMD应用于通常不支持牙周结缔组织附着形成的材料表面可以改变通过这些材料获得的牙周结缔组织界面的类型。

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