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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Mediation of bone ingrowth in porous hydroxyapatite bone graft substitutes
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Mediation of bone ingrowth in porous hydroxyapatite bone graft substitutes

机译：多孔羟基磷灰石骨移植替代物中骨向内生长的介导

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Previous investigations have shown that both the early biological response and the mechanical properties of a porous hydroxyapatite bone graft substitute are highly sensitive to its pore structure. The objective of this study was to evaluate whether the pore structure continued to influence bone integration in the medium to long term. Two screened batches of porous hydroxyapatite (PHA) designated as batch A and batch B, with porosities of approx 60 and 80 percent, respectively, were selected for this study and implanted for periods of 5, 13, and 26 weeks into the lower femur of New Zealand White rabbits. Histomorphometric analysis of the absolute volume of bone ingrowth within batch A and B implants from 5 to 26 weeks showed that the absolute volume of bone ingrowth was consistently lower in batch A (10-21 percent), compared to batch B implants (24-31 percent). However, when the volume of bone ingrowth was normalised for the available pore space, this difference was reduced (23-47 percent and 32-42 percent for batches A and B, respectively). These observations suggest that differences in the volume of bone ingrowth initially depended on pore inter-connectivity rather than pore size, whereas the volume or morphology of the PHA influenced the volume and morphology of bone ingrowth at later time points. Compression testing showed that bone ingrowth had a strong reinforcing effect on PHA bone graft substitutes, and a strong correlation was identified between mechanical properties and the absolute volume of ingrowth for both batches A and B. Furthermore, at 13 and 26 weeks, there was no significant variation in the ultimate compressive strength of integrated batch A and B implants. This similarity in ultimate mechanical properties indicated that the absolute volume of in-growth may be mediated by the PHA structure through its impact on the dynamics of the local biomechanical environment. The results of push-out testing showed that fixation of PHA bone graft substitutes was independent of density within the range studied, with no significant difference in the interfacial shear stress between batches A and B at each time point throughout the study.
机译：先前的研究表明，多孔羟基磷灰石骨移植替代物的早期生物学反应和机械性能均对其孔结构高度敏感。这项研究的目的是评估中长期内孔结构是否继续影响骨整合。本研究选择了两个经过筛选的多孔羟基磷灰石（PHA）批次，分别称为A批次和B批次，孔隙率分别约为60％和80％，并分别植入了股骨下股骨5、13和26周。新西兰白兔。从5到26周的A和B批植入物中骨向内生长的绝对量的组织形态分析表明，与B批植入物相比，A批中骨向内生长的绝对量始终较低（10-21％）（24-31）百分）。但是，当将可用骨孔空间的骨向内生长量标准化时，这种差异会减小（批次A和B分别为23-47％和32-42％）。这些观察结果表明，骨长入量的差异最初取决于孔的相互连通性，而不是孔的大小，而PHA的量或形态在以后的时间点会影响骨长入的量和形态。压缩测试表明，骨长入对PHA骨移植替代物具有很强的增强作用，并且在A和B批的机械性能和绝对长入体积之间发现强相关性。此外，在第13和26周时，没有集成批次A和B植入物的最终抗压强度的显着变化。最终机械性能的这种相似性表明，PHA结构可通过其对局部生物力学环境动力学的影响来介导绝对生长量。推出试验的结果表明，在研究范围内，PHA骨移植替代物的固定与密度无关，在整个研究的每个时间点，批次A和B之间的界面剪切应力均无显着差异。

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