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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Microstructural disassembly of calcium phosphates
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Microstructural disassembly of calcium phosphates

机译：磷酸钙的微结构分解

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Microstructural factors may play a role in the osseointegration of calcium phosphates. In this paper, direct microstructural interactions between crystalline calcium phosphates and the biological milieu are reported. Degradation via exposure to osteoblast culture closely resembles in vivo interactions with subcutaneous tissues in a bovine model at early time periods. That these interactions were common to both experiments constitutes one of the few known examples of in vitro-in vivo correspondence. Interestingly, the degradation of phase pure hydroxyapatite (HA) in vitro was more rapid than that of biphasic HA in vivo. In both cases, grain extraction/pullout was frequently observed. This suggests a connection to smaller-scale observations of epitaxial CHA nucleation and growth on pre-existing HA grains. A microstructure in which the grain boundary is dissolving/corroding can apparently be disassembled by forces transmitted through biological structures. These observations are distinct from those of simple non-biological solutions and prove that biological environments can interact with the material beneath the ceramic-cell/ceramic-tissue interface. Many often ignored microstructural factors grain size, shape, grain boundary strength and the presence of impurity phases-may in fact control degradation. We also suggest that even relatively modest initial grain sizes will, in combination with the mild/absent foreign body response to calcium phosphates, result in lengthy in vivo particle resistence.
机译：微观结构因素可能在磷酸钙的骨整合中起作用。本文报道了结晶磷酸钙与生物环境之间直接的微结构相互作用。暴露于成骨细胞培养物中的降解与牛模型中早期阶段体内与皮下组织的相互作用非常相似。这些相互作用对于两个实验是共同的，构成了体内-体外对应的少数几个已知实例之一。有趣的是，相纯羟基磷灰石（HA）的体外降解比体内双相HA的降解更快。在两种情况下，都经常观察到谷物提取/拉出。这表明与先前存在的HA晶粒上外延CHA成核和生长的小规模观测结果有关。明显地，通过生物结构传递的力可以分解其中晶界溶解/腐蚀的微观结构。这些观察结果不同于简单的非生物方法的观察结果，并证明生物环境可以与陶瓷细胞/陶瓷组织界面下的物质相互作用。许多经常被忽略的微观结构因素，例如晶粒尺寸，形状，晶界强度和杂质相的存在，实际上可以控制其降解。我们还建议，即使相对适中的初始晶粒尺寸，再加上对磷酸钙的轻度/不存在异物反应，都会导致体内颗粒的持久保留。

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