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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >A comparison of ProOsteon, DBX, and collagraft in a rabbit model.
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A comparison of ProOsteon, DBX, and collagraft in a rabbit model.

机译：ProOsteon，DBX和同种异体移植物在兔模型中的比较。

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摘要

Many bone graft substitutes (BGSs) have been developed and are commercially available. These products differ in the tailoring of their properties, including size, form, osteoconductivity, osteoinductivity, and resorption kinetics. Differential enhancement of these properties may optimize the performance of these materials for varying applications. BGSs offer an opportunity to lessen morbidity of harvesting and use of autogenous and/or allograft bone. The purpose of this study is to quantitatively compare the magnitude of bony ingrowth and biodegradation of different commercially available BGS materials in a rabbit femoral defect model. BGSs from each of three classes (ceramic (ProOsteon), demineralized bone matrix (DBX), and composite (Collagraft)) were implanted in cylindrical defects in bilateral femoral condyles of 12 adult New Zealand White rabbits. Each of the three BGS materials and the empty controls were compared. The specimens were harvested at 3 months postimplantation for radiographic and histologic evaluation. Histomorphometry yielded resorption of graft material remaining in the index defect. Magnitude of bony ingrowth was assessed based on an 8-bit 256 densitometry model. Histomorphometric analysis of the data demonstrated statistical differences in the resorption and magnitude of bony ingrowth of the three BGS materials. The three BGS were significantly different for ingrowth (p = 0.046) when using the Wilcoxon Test. The ceramic graft material averaged 47% bony ingrowth. Rabbit-based DBX material showed extensive osseous ingrowth (35%) and the composite graft material demonstrated significant bony ingrowth (56%). The control, as anticipated, showed the least amount of bony ingrowth (29%). Fisher's Exact Test yielded statistical differences (p = 0.0003) when comparisons for resorption were conducted. An ideal BGS material should be biocompatible, be able to withstand the local load environment for a given application, degrade in concert with bony replacement, and be both osteoinductive and osteoconductive. This in-vivo, head-to-head comparison of three commercially available BGS materials in an animal model compares these characteristics and demonstrates differences between them, which may act as a guide in the use of these products in human applications.
机译：已经开发了许多骨移植替代物（BGS），并且可以商购获得。这些产品在其性质的定制方面有所不同，包括大小，形式，骨传导性，骨传导性和吸收动力学。这些性能的差异增强可以优化这些材料在各种应用中的性能。 BGS提供了减少自体和/或同种异体骨收获和使用率的机会。这项研究的目的是在兔股骨缺损模型中定量比较不同市售BGS材料的骨向内生长和生物降解程度。将三类（陶瓷（ProOsteon），软化骨基质（DBX）和复合材料（Collagraft））中的每种BGS植入12只成年新西兰白兔的双侧股骨con的圆柱形缺损中。比较了三种BGS材料和空对照。植入后3个月收集标本进行影像学和组织学评估。组织形态计量学使得保留在指数缺损中的移植物材料吸收。根据8位256密度测定模型评估骨长入的幅度。数据的组织形态分析表明，三种BGS材料的吸收和骨向内生长的大小存在统计学差异。当使用Wilcoxon检验时，三个BGS的向内生长显着不同（p = 0.046）。陶瓷接枝材料的骨长入平均为47％。兔基DBX材料显示出广泛的骨长入（35％），而复合移植材料显示出明显的骨长入（56％）。如预期的那样，对照组的骨内生最少（29％）。当进行吸收比较时，Fisher精确检验产生了统计学差异（p = 0.0003）。理想的BGS材料应具有生物相容性，能够承受给定应用的局部负载环境，与骨替代物协同降解，并且具有骨诱导性和骨传导性。这种在动物模型中对三种市售BGS材料的体内，头对头比较比较了这些特性并证明了它们之间的差异，这可以作为在人体应用中使用这些产品的指南。

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